| Literature DB >> 11093248 |
F S Espindola1, D M Suter, L B Partata, T Cao, J S Wolenski, R E Cheney, S M King, M S Mooseker.
Abstract
Class V myosins are a ubiquitously expressed family of actin-based molecular motors. Biochemical studies on myosin-Va from chick brain indicate that this myosin is a two-headed motor with multiple calmodulin light chains associated with the regulatory or neck domain of each heavy chain, a feature consistent with the regulatory effects of Ca(2+) on this myosin. In this study, the identity of three additional low molecular weight proteins of 23-,17-, and 10 kDa associated with myosin-Va is established. The 23- and 17-kDa subunits are both members of the myosin-II essential light chain gene family, encoded by the chicken L23 and L17 light chain genes, respectively. The 10-kDa subunit is a protein originally identified as a light chain (DLC8) of flagellar and axonemal dynein. The 10-kDa subunit is associated with the tail domain of myosin-Va. Copyright 2000 Wiley-Liss, Inc.Entities:
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Year: 2000 PMID： 11093248 DOI： 10.1002/1097-0169(200012)47:4<269::AID-CM2>3.0.CO;2-G
Source DB: PubMed Journal: Cell Motil Cytoskeleton ISSN： 0886-1544