OBJECTIVE: To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS). BACKGROUND: Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear. METHOD: Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task). RESULTS: Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls. CONCLUSIONS: Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.
OBJECTIVE: To identify working memory (WM) impairment by examining components of auditory working memory with the same sample of individuals with multiple sclerosis (MS). BACKGROUND: Although individuals with MS have consistently demonstrated WM impairments, the specific components involved (i.e., central executive versus storage/maintenance) remain unclear. METHOD: Individuals with MS with and without cognitive impairment and healthy controls were administered a task primarily assessing storage and rehearsal/maintenance (auditory n-back) and a task with a significant central executive component (Paced Auditory Serial Addition Task). RESULTS: Results indicate when the phonological loop is minimally challenged, maintenance of information is generally efficient. However, the addition of a central executive component to processing appears to be the key factor in differentiating individuals with MS with cognitive impairment from those without cognitive impairment and healthy controls. CONCLUSIONS: Results indicated that the primary WM impairment in MS is within the central executive rather than the phonological loop.
Authors: Eldar Eftekhari; Seyed-Parsa Hojjat; Rita Vitorino; Timothy J Carroll; Charles Grady Cantrell; Liesly Lee; Matthew W Taylor; Sarah A Morrow; Haddas Benhabib; Richard I Aviv; Andrea Kassner Journal: Neuroradiology Date: 2017-06-16 Impact factor: 2.804
Authors: Helen M Genova; Jeannie Lengenfelder; Nancy D Chiaravalloti; Nancy B Moore; John DeLuca Journal: Appl Neuropsychol Adult Date: 2012 Impact factor: 2.248