M Huiskamp1, E Dobryakova2, G D Wylie3, J DeLuca4, N D Chiaravalloti5. 1. Neuropsychology and Neuroscience Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States. 2. Traumatic Brain Injury Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Department of Physical Medicine and Rehabilitation, Rutgers - New Jersey Medical School, 90 Bergen Street, Newark, NJ 07103, United States. 3. Neuropsychology and Neuroscience Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Department of Physical Medicine and Rehabilitation, Rutgers - New Jersey Medical School, 90 Bergen Street, Newark, NJ 07103, United States. 4. Neuropsychology and Neuroscience Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Traumatic Brain Injury Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Department of Physical Medicine and Rehabilitation, Rutgers - New Jersey Medical School, 90 Bergen Street, Newark, NJ 07103, United States; Department of Neurosciences, Rutgers - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07101, United States. 5. Neuropsychology and Neuroscience Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Traumatic Brain Injury Laboratory, Kessler Foundation, 300 Executive Drive, Suite 70, West Orange, NJ 07052, United States; Department of Physical Medicine and Rehabilitation, Rutgers - New Jersey Medical School, 90 Bergen Street, Newark, NJ 07103, United States. Electronic address: nchiaravalloti@KesslerFoundation.org.
Abstract
BACKGROUND: Working memory deficits are common in multiple sclerosis (MS). The modified Story Memory Technique (mSMT) has been shown to improve new learning and memory in MS, but its effects on working memory (WM) are currently unknown. OBJECTIVE: The present study presents a secondary analysis of data from a larger double-blind, placebo-controlled, randomized clinical trial and examines changes in cerebral activation on a WM task following mSMT treatment. METHODS:Sixteen participants with clinically definite MS were randomly assigned to treatment (n=7) or placebo-control groups (n=9) matched for gender, age and education. Baseline and immediate follow-up functional Magnetic Resonance Imaging (fMRI) was obtained for all subjects. During fMRI participants completed an N-back task, consisting of 0-, 1-and 2-back conditions. RESULTS: Significant increases in cerebral activation were noted in the dorsolateral prefrontal cortex, supplementary motor area and inferior parietal lobule at follow-up in the treatment group. No significant changes were noted in the placebo control group. CONCLUSION: Due to the small sample size, results of the current study should be interpreted as preliminary. However, the observed pattern of activation of the frontoparietal network involved in WM found in the treatment group, suggests that mSMT training increases recruitment of attention- and WM-related neural networks. We conclude that mSMT treatment leads to changes in WM-related cerebral activation.
RCT Entities:
BACKGROUND:Working memory deficits are common in multiple sclerosis (MS). The modified Story Memory Technique (mSMT) has been shown to improve new learning and memory in MS, but its effects on working memory (WM) are currently unknown. OBJECTIVE: The present study presents a secondary analysis of data from a larger double-blind, placebo-controlled, randomized clinical trial and examines changes in cerebral activation on a WM task following mSMT treatment. METHODS: Sixteen participants with clinically definite MS were randomly assigned to treatment (n=7) or placebo-control groups (n=9) matched for gender, age and education. Baseline and immediate follow-up functional Magnetic Resonance Imaging (fMRI) was obtained for all subjects. During fMRI participants completed an N-back task, consisting of 0-, 1-and 2-back conditions. RESULTS: Significant increases in cerebral activation were noted in the dorsolateral prefrontal cortex, supplementary motor area and inferior parietal lobule at follow-up in the treatment group. No significant changes were noted in the placebo control group. CONCLUSION: Due to the small sample size, results of the current study should be interpreted as preliminary. However, the observed pattern of activation of the frontoparietal network involved in WM found in the treatment group, suggests that mSMT training increases recruitment of attention- and WM-related neural networks. We conclude that mSMT treatment leads to changes in WM-related cerebral activation.
Authors: John DeLuca; Gordon J Chelune; David S Tulsky; Jean Lengenfelder; Nancy D Chiaravalloti Journal: J Clin Exp Neuropsychol Date: 2004-06 Impact factor: 2.475
Authors: W I McDonald; A Compston; G Edan; D Goodkin; H P Hartung; F D Lublin; H F McFarland; D W Paty; C H Polman; S C Reingold; M Sandberg-Wollheim; W Sibley; A Thompson; S van den Noort; B Y Weinshenker; J S Wolinsky Journal: Ann Neurol Date: 2001-07 Impact factor: 10.422
Authors: Lauren A Taylor; Jacqueline R Mhizha-Murira; Laura Smith; Kristy-Jane Potter; Dana Wong; Nikos Evangelou; Nadina B Lincoln; Roshan das Nair Journal: Cochrane Database Syst Rev Date: 2021-10-18