| Literature DB >> 14763558 |
Haiyin He1, Ramunas Bigelis, Eric H Solum, Michael Greenstein, Guy T Carter.
Abstract
Acremonidins A to approximately E (1 to approximately 5) were produced by fermentation of Acremonium sp., LL-Cyan 416, in heterogeneous phases. The structures of these compounds, containing a bridging keto group, were determined by spectroscopic analysis. Acremonidins A and B showed moderate activity against Gram-positive bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci. Selective acylations of acremonidin B afforded ester derivatives 6 to approximately 9 that exhibited improved antibacterial activity.Entities:
Mesh:
Substances:
Year: 2003 PMID: 14763558 DOI: 10.7164/antibiotics.56.923
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN: 0021-8820 Impact factor: 2.649