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Literature DB >> 14759362

Reprogrammed genetic decoding in cellular gene expression.

Olivier Namy¹, Jean-Pierre Rousset, Sawsan Napthine, Ian Brierley.

Abstract

Reprogrammed genetic decoding signals in mRNAs productively overwrite the normal decoding rules of translation. These "recoding" signals are associated with sites of programmed ribosomal frameshifting, hopping, termination codon suppression, and the incorporation of the unusual amino acids selenocysteine and pyrrolysine. This review summarizes current knowledge of the structure and function of recoding signals in cellular genes, the biological importance of recoding in gene regulation, and ways to identify new recoded genes.

Entities: Chemical

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Year: 2004 PMID： 14759362 DOI： 10.1016/s1097-2765(04)00031-0

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

123 in total

Review 1. Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.

Authors: Anthony Griffiths
Journal: Drug Resist Updat Date: 2011-09-22 Impact factor: 18.500

2. From cis-regulatory elements to complex RNPs and back.

Authors: Fátima Gebauer; Thomas Preiss; Matthias W Hentze
Journal: Cold Spring Harb Perspect Biol Date: 2012-07-01 Impact factor: 10.005

3. The distinction between recoding and codon reassignment.

Authors: John F Atkins; Pavel V Baranov
Journal: Genetics Date: 2010-08 Impact factor: 4.562

Review 4. Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning.

Authors: Pavel V Baranov; John F Atkins; Martina M Yordanova
Journal: Nat Rev Genet Date: 2015-08-11 Impact factor: 53.242

5. A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites.

Authors: Alexander Koch; Daria Gawron; Sandra Steyaert; Elvis Ndah; Jeroen Crappé; Sarah De Keulenaer; Ellen De Meester; Ming Ma; Ben Shen; Kris Gevaert; Wim Van Criekinge; Petra Van Damme; Gerben Menschaert
Journal: Proteomics Date: 2014-10-02 Impact factor: 3.984

Reprogrammed genetic decoding in cellular gene expression.

Review 1. Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.

2. From cis-regulatory elements to complex RNPs and back.

3. The distinction between recoding and codon reassignment.

Review 4. Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning.

5. A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites.

6. Identification of programmed translational -1 frameshifting sites in the genome of Saccharomyces cerevisiae.

Review 7. Interrupted genes in extremophilic archaea: mechanisms of gene expression in early organisms.

8. Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons.

9. RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs.

10. Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotides.