| Literature DB >> 14756693 |
Junko Hiraoka-Yamamoto1, Yasuo Nara, Naomi Yasui, Yuko Onobayashi, Satoru Tsuchikura, Katsumi Ikeda.
Abstract
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.Entities:
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Year: 2004 PMID： 14756693 DOI： 10.1111/j.1440-1681.2004.03962.x
Source DB: PubMed Journal: Clin Exp Pharmacol Physiol ISSN： 0305-1870 Impact factor: 2.557