Literature DB >> 31228162

Rat Models of Metabolic Syndrome.

Anne E Kwitek1.   

Abstract

Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutant models, or are congenic strains derived from a combination of these models. Together they can be studied to identify the genetic and physiological underpinnings of MetS to identify candidate genes or mechanisms for study in human MetS subjects.

Entities:  

Keywords:  Hypertension; MetS; Metabolic syndrome; Obesity; Rat disease model; Rat genetic model; Rat inbred model

Mesh：

Substances：

Year:  2019        PMID： 31228162      PMCID： PMC7315404          DOI： 10.1007/978-1-4939-9581-3_13

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  119 in total

1.  Salt sensitivity in genetically hypertensive rats of the Lyon strain.

Authors:  M Florin; M Lo; K L Liu; J Sassard
Journal:  Kidney Int       Date:  2001-05       Impact factor: 10.612

Review 2.  The GK rat: a prototype for the study of non-overweight type 2 diabetes.

Authors:  Bernard Portha; Marie-Hélène Giroix; Cecile Tourrel-Cuzin; Hervé Le-Stunff; Jamileh Movassat
Journal:  Methods Mol Biol       Date:  2012

3.  Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.

Authors:  Marc-Emmanuel Dumas; Steven P Wilder; Marie-Thérèse Bihoreau; Richard H Barton; Jane F Fearnside; Karène Argoud; Lisa D'Amato; Robert H Wallis; Christine Blancher; Hector C Keun; Dorrit Baunsgaard; James Scott; Ulla Grove Sidelmann; Jeremy K Nicholson; Dominique Gauguier
Journal:  Nat Genet       Date:  2007-04-15       Impact factor: 38.330

4.  Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.

Authors:  Takeshi K Watanabe; Mikio Suzuki; Yuki Yamasaki; Shiro Okuno; Haretsugu Hishigaki; Toshihide Ono; Keiko Oga; Ayako Mizoguchi-Miyakita; Atsushi Tsuji; Naohide Kanemoto; Shigeyuki Wakitani; Toshihisa Takagi; Yusuke Nakamura; Akira Tanigami
Journal:  Clin Exp Pharmacol Physiol       Date:  2005 May-Jun       Impact factor: 2.557

5.  Genetic selection for voluntary alcohol consumption in the albino rat.

Authors:  K Eriksson
Journal:  Science       Date:  1968-02-16       Impact factor: 47.728

6.  Abnormalities of carbohydrate and lipid metabolism in Dahl rats.

Authors:  G M Reaven; J Twersky; H Chang
Journal:  Hypertension       Date:  1991-11       Impact factor: 10.190

7.  Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.

Authors:  Masanori Fuse; Norihide Yokoi; Masami Shinohara; Taku Masuyama; Riko Kitazawa; Sohei Kitazawa; Susumu Seino
Journal:  Physiol Genomics       Date:  2008-07-08       Impact factor: 3.107

8.  Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.

Authors:  K Takaya; Y Ogawa; N Isse; T Okazaki; N Satoh; H Masuzaki; K Mori; N Tamura; K Hosoda; K Nakao
Journal:  Biochem Biophys Res Commun       Date:  1996-08-05       Impact factor: 3.575

9.  Genomic landscape of rat strain and substrain variation.

Authors:  Roel Hermsen; Joep de Ligt; Wim Spee; Francis Blokzijl; Sebastian Schäfer; Eleonora Adami; Sander Boymans; Stephen Flink; Ruben van Boxtel; Robin H van der Weide; Tim Aitman; Norbert Hübner; Marieke Simonis; Boris Tabakoff; Victor Guryev; Edwin Cuppen
Journal:  BMC Genomics       Date:  2015-05-06       Impact factor: 3.969

Review 10.  The Global Epidemic of the Metabolic Syndrome.

Authors:  Mohammad G Saklayen
Journal:  Curr Hypertens Rep       Date:  2018-02-26       Impact factor: 5.369
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  5 in total

Review 1.  mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly.

Authors:  Tristan V de Jong; Hao Chen; Wesley A Brashear; Kelli J Kochan; Andrew E Hillhouse; Yaming Zhu; Isha S Dhande; Elizabeth A Hudson; Mary H Sumlut; Melissa L Smith; Theodore S Kalbfleisch; Peter A Doris
Journal:  Physiol Genomics       Date:  2022-05-11       Impact factor: 4.297

2.  Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene.

Authors:  Karen C Clark; Valerie A Wagner; Katie L Holl; John J Reho; Monika Tutaj; Jennifer R Smith; Melinda R Dwinell; Justin L Grobe; Anne E Kwitek
Journal:  Front Genet       Date:  2022-06-24       Impact factor: 4.772

Review 3.  Metabolic Syndrome: Lessons from Rodent and Drosophila Models.

Authors:  Myroslava V Vatashchuk; Maria M Bayliak; Viktoria V Hurza; Kenneth B Storey; Volodymyr I Lushchak
Journal:  Biomed Res Int       Date:  2022-06-22       Impact factor: 3.246

4.  Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents.

Authors:  John J Reho; Pablo Nakagawa; Gary C Mouradian; Connie C Grobe; Fatima L Saravia; Colin M L Burnett; Anne E Kwitek; John R Kirby; Jeffrey L Segar; Matthew R Hodges; Curt D Sigmund; Justin L Grobe
Journal:  Front Physiol       Date:  2022-02-25       Impact factor: 4.755

Review 5.  Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations.

Authors:  Trisha A Jenkins
Journal:  Curr Diab Rep       Date:  2022-06-23       Impact factor: 5.430
  5 in total

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