| Literature DB >> 14751759 |
Fumihiko Takeshita1, Ihsan Gursel, Ken J Ishii, Koichi Suzuki, Mayda Gursel, Dennis M Klinman.
Abstract
Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14751759 DOI： 10.1016/j.smim.2003.10.009
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130