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Literature DB >> 16135562

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells.

Geanncarlo Lugo-Villarino¹, Shu-Ichi Ito, Dennis M Klinman, Laurie H Glimcher.

Abstract

Treatment with synthetic oligodeoxynucleotides containing CpG motifs (CpG ODNs) is remarkably protective against otherwise lethal infection. Here, we describe an essential role for the transcription factor T-bet in mediating the protective function of CpG ODNs. Loss of T-bet in conventional CD11c(hi) dendritic cells (DCs) and in plasmacytoid DCs impaired production of IFNs. Strikingly, in contrast to Rag2-/- mice, Rag2-/- mice that also lacked T-bet (DKO) could not be rescued from lethal Listeria monocytogenes infection by prior treatment with CpG ODN. Rescue was achieved by adoptive transfer of CD11c(hi) DCs from WT, but not T-bet-/-, CpG ODN-treated donor mice. We conclude that T-bet in DCs is required for the adjuvant activity of CpG ODN in infection, revealing its vital role in innate immunity.

Entities: Chemical Gene Species

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Year: 2005 PMID： 16135562 PMCID： PMC1201626 DOI： 10.1073/pnas.0506638102

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

Review 1. CpG motifs in bacterial DNA and their immune effects.

Authors: Arthur M Krieg
Journal: Annu Rev Immunol Date: 2001-10-04 Impact factor: 28.527

Review 2. Now I know my CpGs.

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Journal: Trends Microbiol Date: 2001-06 Impact factor: 17.079

Review 3. Molecular mechanisms regulating Th1 immune responses.

Authors: Susanne J Szabo; Brandon M Sullivan; Stanford L Peng; Laurie H Glimcher
Journal: Annu Rev Immunol Date: 2001-12-19 Impact factor: 28.527

4. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.

Authors: A A Lighvani; D M Frucht; D Jankovic; H Yamane; J Aliberti; B D Hissong; B V Nguyen; M Gadina; A Sher; W E Paul; J J O'Shea
Journal: Proc Natl Acad Sci U S A Date: 2001-12-18 Impact factor: 11.205

5. Dendritic cells are early cellular targets of Listeria monocytogenes after intestinal delivery and are involved in bacterial spread in the host.

Authors: B Pron; C Boumaila; F Jaubert; P Berche; G Milon; F Geissmann; J L Gaillard
Journal: Cell Microbiol Date: 2001-05 Impact factor: 3.715

6. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Authors: Susanne J Szabo; Brandon M Sullivan; Claudia Stemmann; Abhay R Satoskar; Barry P Sleckman; Laurie H Glimcher
Journal: Science Date: 2002-01-11 Impact factor: 47.728

Review 7. Immunity to Listeria infection.

Authors: B T Edelson; E R Unanue
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8. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet.

Authors: Sing Sing Way; Christopher B Wilson
Journal: J Immunol Date: 2004-11-15 Impact factor: 5.422

9. CpG ODN-mediated regulation of IL-12 p40 transcription.

Authors: F Takeshita; D M Klinman
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10. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells.

Authors: Geanncarlo Lugo-Villarino; Roberto Maldonado-Lopez; Richard Possemato; Cristina Penaranda; Laurie H Glimcher
Journal: Proc Natl Acad Sci U S A Date: 2003-06-11 Impact factor: 11.205

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2. The Trophic Life Cycle Stage of the Opportunistic Fungal Pathogen Pneumocystis murina Hinders the Ability of Dendritic Cells To Stimulate CD4⁺ T Cell Responses.

Authors: Heather M Evans; Andrew Simpson; Shu Shen; Arnold J Stromberg; Carol L Pickett; Beth A Garvy
Journal: Infect Immun Date: 2017-09-20 Impact factor: 3.441

3. Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Authors: Ce Feng Liu; Gabriel S Brandt; Quyen Q Hoang; Natalia Naumova; Vanja Lazarevic; Eun Sook Hwang; Job Dekker; Laurie H Glimcher; Dagmar Ringe; Gregory A Petsko
Journal: Proc Natl Acad Sci U S A Date: 2016-10-10 Impact factor: 11.205

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells.

Review 1. CpG motifs in bacterial DNA and their immune effects.

Review 2. Now I know my CpGs.

Review 3. Molecular mechanisms regulating Th1 immune responses.

4. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.

5. Dendritic cells are early cellular targets of Listeria monocytogenes after intestinal delivery and are involved in bacterial spread in the host.

6. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Review 7. Immunity to Listeria infection.

8. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet.

9. CpG ODN-mediated regulation of IL-12 p40 transcription.

10. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells.

Review 1. T-bet in disease.

2. The Trophic Life Cycle Stage of the Opportunistic Fungal Pathogen Pneumocystis murina Hinders the Ability of Dendritic Cells To Stimulate CD4⁺ T Cell Responses.

3. Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

4. Combined Tbet and IL12 gene therapy elicits and recruits superior antitumor immunity in vivo.

5. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice.

6. Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression.

7. IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.

8. T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.

9. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity.

10. T-bet plays a key role in NK-mediated control of melanoma metastatic disease.