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Literature DB >> 14747578

Distribution of hydrophobic residues is crucial for the fusogenic properties of the Ebola virus GP2 fusion peptide.

B Adam¹, L Lins, V Stroobant, A Thomas, R Brasseur.

Abstract

The lipid-destabilizing properties of the N-terminal domain of the GP2 of Ebola virus were investigated. Our results suggest that the domain of Ebola virus needed for fusion is shorter than that previously reported. The fusogenic properties of this domain are related to its oblique orientation at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.

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Year: 2004 PMID： 14747578 PMCID： PMC369453 DOI： 10.1128/jvi.78.4.2131-2136.2004

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

33 in total

Review 1. Fusion peptides and the mechanism of viral fusion.

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Journal: Biochim Biophys Acta Date: 2003-07-11

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Journal: Biochem Biophys Res Commun Date: 1991-03-29 Impact factor: 3.575

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Journal: J Virol Date: 1994-02 Impact factor: 5.103

7. Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion.

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Journal: FEBS Lett Date: 2003-01-30 Impact factor: 4.124

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9. Fusogenic segments of bovine leukemia virus and simian immunodeficiency virus are interchangeable and mediate fusion by means of oblique insertion in the lipid bilayer of their target cells.

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Journal: Proc Natl Acad Sci U S A Date: 1992-05-01 Impact factor: 11.205

10. Theoretical and functional analysis of the SIV fusion peptide.

Authors: M Horth; B Lambrecht; M C Khim; F Bex; C Thiriart; J M Ruysschaert; A Burny; R Brasseur
Journal: EMBO J Date: 1991-10 Impact factor: 11.598

11 in total

1. Studies on viral fusion peptides: the distribution of lipophilic and electrostatic potential over the peptide determines the angle of insertion into a membrane.

Authors: A Taylor; M S P Sansom
Journal: Eur Biophys J Date: 2010-05-25 Impact factor: 1.733

Review 2. Learning from the viral journey: how to enter cells and how to overcome intracellular barriers to reach the nucleus.

Authors: Diky Mudhakir; Hideyoshi Harashima
Journal: AAPS J Date: 2009-02-05 Impact factor: 4.009

Review 3. Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.

Authors: Judith M White; Sue E Delos; Matthew Brecher; Kathryn Schornberg
Journal: Crit Rev Biochem Mol Biol Date: 2008 May-Jun Impact factor: 8.250

Review 4. Rodent-Adapted Filoviruses and the Molecular Basis of Pathogenesis.

Authors: Logan Banadyga; Michael A Dolan; Hideki Ebihara
Journal: J Mol Biol Date: 2016-05-14 Impact factor: 5.469

5. Plasma membrane localization of Solanum tuberosum remorin from group 1, homolog 3 is mediated by conformational changes in a novel C-terminal anchor and required for the restriction of potato virus X movement].

Authors: Artemis Perraki; Jean-Luc Cacas; Jean-Marc Crowet; Laurence Lins; Michel Castroviejo; Sylvie German-Retana; Sébastien Mongrand; Sylvain Raffaele
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Review 6. Filovirus entry: a novelty in the viral fusion world.

Authors: Catherine L Hunt; Nicholas J Lennemann; Wendy Maury
Journal: Viruses Date: 2012-02-07 Impact factor: 5.048

Review 7. Molecular mechanisms of Ebola virus pathogenesis: focus on cell death.

Authors: L Falasca; C Agrati; N Petrosillo; A Di Caro; M R Capobianchi; G Ippolito; M Piacentini
Journal: Cell Death Differ Date: 2015-05-29 Impact factor: 15.828

Review 8. Host cell factors in filovirus entry: novel players, new insights.

Authors: Heike Hofmann-Winkler; Franziska Kaup; Stefan Pöhlmann
Journal: Viruses Date: 2012-12 Impact factor: 5.048

Review 9. The three lives of viral fusion peptides.

Authors: Beatriz Apellániz; Nerea Huarte; Eneko Largo; José L Nieva
Journal: Chem Phys Lipids Date: 2014-04-02 Impact factor: 3.329

Review 10. Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus.

Authors: Kuldeep Dhama; Kumaragurubaran Karthik; Rekha Khandia; Sandip Chakraborty; Ashok Munjal; Shyma K Latheef; Deepak Kumar; Muthannan Andavar Ramakrishnan; Yashpal Singh Malik; Rajendra Singh; Satya Veer Singh Malik; Raj Kumar Singh; Wanpen Chaicumpa
Journal: Front Immunol Date: 2018-08-10 Impact factor: 7.561