| Literature DB >> 14746873 |
Jian-Hua Liu1, Jie Yan, Shou-Xiang Yi, Xiao-Rong Chang, Ya-Ping Lin, Ji-Ming Hu.
Abstract
Acupuncture has been widely applied to treat gastrointestinal diseases in the clinic. However, its precise mechanism remains unknown. In the present study, effects of electroacupuncture (EA) at Zusanli acupoints (ST36) on gastric myoelectric activity and substance P (SP) in the dorsal vagal complex (DVC) were observed. EA at ST36 significantly increased the frequency of slow waves and the frequency of the spike potentials superimposed on the slow waves, which persisted for 90 min after cessation of EA and was completely abolished after bilateral vagotomy. Meanwhile, the mean optical density of SP immunoreactive fibers in the DVC increased following EA. The results suggested that EA at ST36 promoted the gastric myoelectric activity, which was regulated by the vagus, and SP in the DVC may be involved in the excitatory effects. Furthermore, EA had a relative long-term post-effect. We presumed that DVC may be a supraspinal center in the effect of EA on gastric function.Entities:
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Year: 2004 PMID： 14746873 DOI： 10.1016/j.neulet.2003.11.044
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046