Literature DB >> 14746360

Prevention and treatment of excessive dermal scarring.

Ingrid E Roseborough1, Mark A Grevious, Raphael C Lee.   

Abstract

Today, wound management to avoid excessive scar formation is increasingly important, especially in populations with Fitzpatrick 3 or higher skin pigmentation. Medical science and industrial development are devoting more effort toward understanding and offering better therapy to control scars. However, advances in scar management have been hampered by the confusing or ambiguous terminology. There is no consensus on what amount of post-traumatic skin scar formation is "normal" and what should be considered "hypertrophic". In the World Health Organization's ICD-9, there is no diagnostic code for hypertrophic scar--only keloid is listed. Yet, the medical and scientific literature distinguishes them as different conditions. Our experience suggests that the diagnosis of keloid disease is greatly over-rendered. For black patients, an elevated scar seems, by default, diagnosed as keloid by most. This confusion results in inappropriate management of scar formation, and occasionally contributes to decision making related to elective or cosmetic surgery. Given that patients are expecting better outcomes from wound care today than in the past, this review article attempts to capture the essential biological factors related to wound scar production and discusses treatment options and indications used by the authors.

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Year:  2004        PMID: 14746360      PMCID: PMC2594768     

Source DB:  PubMed          Journal:  J Natl Med Assoc        ISSN: 0027-9684            Impact factor:   1.798


  45 in total

1.  Elevated levels of testosterone receptors in keloid tissue: an experimental investigation.

Authors:  H P Schierle; D Scholz; G Lemperle
Journal:  Plast Reconstr Surg       Date:  1997-08       Impact factor: 4.730

2.  A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids.

Authors:  T J Phillips; A D Gerstein; V Lordan
Journal:  Dermatol Surg       Date:  1996-09       Impact factor: 3.398

Review 3.  Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy.

Authors:  E E Tredget; B Nedelec; P G Scott; A Ghahary
Journal:  Surg Clin North Am       Date:  1997-06       Impact factor: 2.741

4.  Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings.

Authors:  C H Ricketts; L Martin; D T Faria; G M Saed; D P Fivenson
Journal:  Dermatol Surg       Date:  1996-11       Impact factor: 3.398

5.  Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.

Authors:  J G Crowston; A N Akbar; P H Constable; N L Occleston; J T Daniels; P T Khaw
Journal:  Invest Ophthalmol Vis Sci       Date:  1998-02       Impact factor: 4.799

Review 6.  The molecular basis of keloid and hypertrophic scar formation.

Authors:  T L Tuan; L S Nichter
Journal:  Mol Med Today       Date:  1998-01

Review 7.  The 1996 Lindberg Award. Calcium antagonists alter cell shape and induce procollagenase synthesis in keloid and normal human dermal fibroblasts.

Authors:  H Doong; S Dissanayake; T R Gowrishankar; M C LaBarbera; R C Lee
Journal:  J Burn Care Rehabil       Date:  1996 Nov-Dec

8.  Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature.

Authors:  A P Sclafani; L Gordon; M Chadha; T Romo
Journal:  Dermatol Surg       Date:  1996-06       Impact factor: 3.398

9.  Silicone gel sheeting in scar therapy.

Authors:  B E Katz
Journal:  Cutis       Date:  1995-07

10.  Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars.

Authors:  J E Fulton
Journal:  Dermatol Surg       Date:  1995-11       Impact factor: 3.398

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  13 in total

1.  The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers: an experimental and clinical study.

Authors:  Dimitrios Dionyssiou; Efterpi Demiri; Pericles Foroglou; Aggeliki Cheva; Nikolaos Saratzis; Constantine Aivazidis; George Karkavelas
Journal:  Int Wound J       Date:  2012-06-04       Impact factor: 3.315

2.  Collagen fibril formation. A new target to limit fibrosis.

Authors:  Hye Jin Chung; Andrzej Steplewski; Kee Yang Chung; Jouni Uitto; Andrzej Fertala
Journal:  J Biol Chem       Date:  2008-07-23       Impact factor: 5.157

Review 3.  Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.

Authors:  Anna I Arno; Gerd G Gauglitz; Juan P Barret; Marc G Jeschke
Journal:  Burns       Date:  2014-04-24       Impact factor: 2.744

4.  Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Authors:  Michelle A Ouimet; Renata Fogaça; Sabrina S Snyder; Sameer Sathaye; Luiz H Catalani; Darrin J Pochan; Kathryn E Uhrich
Journal:  Macromol Biosci       Date:  2014-10-21       Impact factor: 4.979

5.  [Hyperplastic scars and keloids. Part I: basics and prevention].

Authors:  A Baisch; F Riedel
Journal:  HNO       Date:  2006-11       Impact factor: 1.284

6.  Polymethacrylate microparticles gel for topical drug delivery.

Authors:  Hagar Ibrahim Labouta; Labiba K El-Khordagui
Journal:  Pharm Res       Date:  2010-07-24       Impact factor: 4.200

7.  Tunable drug release profiles from salicylate-based poly(anhydride-ester) matrices using small molecule admixtures.

Authors:  Michelle A Ouimet; Sabrina S Snyder; Kathryn E Uhrich
Journal:  J Bioact Compat Polym       Date:  2012-11-01       Impact factor: 1.756

8.  Effect of human Wharton's jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts.

Authors:  Anna I Arno; Saeid Amini-Nik; Patrick H Blit; Mohammed Al-Shehab; Cassandra Belo; Elaine Herer; Marc G Jeschke
Journal:  Stem Cells Transl Med       Date:  2014-01-16       Impact factor: 6.940

9.  Inhibition of collagen fibril formation.

Authors:  Andrzej Steplewski; Andrzej Fertala
Journal:  Fibrogenesis Tissue Repair       Date:  2012-06-06

10.  Surgical Adhesive Drape (IO-ban) as Postoperative Surgical Site Dressing.

Authors:  Daniel Felbaum; Hasan R Syed; Rita Snyder; Jason E McGowan; Ribhu T Jha; Mani N Nair
Journal:  Cureus       Date:  2015-12-04
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