PURPOSE: To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during beta-adrenergic stimulation. MATERIALS AND METHODS: Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast-field echo (FFE) with a spatial resolution of 2.7 x 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 microg/kg/minute). RESULTS: Stroke volume increased from a median of 99 mL (range: 68-142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87-180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second [433-497 mL] to 651 mL/second [496-1096 mL/second]) (P < 0.05) and atrial (A) peak filling rate (238 mL/second [183-352 mL/second] to 341 mL/second [230-538 mL/second]) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation. CONCLUSION: Conventional free breathing FFE has the ability to measure the effects of beta-adrenergic stimulation on left ventricular filling. Copyright 2004 Wiley-Liss, Inc.
PURPOSE: To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during beta-adrenergic stimulation. MATERIALS AND METHODS: Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast-field echo (FFE) with a spatial resolution of 2.7 x 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 microg/kg/minute). RESULTS:Stroke volume increased from a median of 99 mL (range: 68-142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87-180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second [433-497 mL] to 651 mL/second [496-1096 mL/second]) (P < 0.05) and atrial (A) peak filling rate (238 mL/second [183-352 mL/second] to 341 mL/second [230-538 mL/second]) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation. CONCLUSION: Conventional free breathing FFE has the ability to measure the effects of beta-adrenergic stimulation on left ventricular filling. Copyright 2004 Wiley-Liss, Inc.
Authors: Akshay Goel; Roderick McColl; Kevin S King; Anthony Whittemore; Ronald M Peshock Journal: J Magn Reson Imaging Date: 2013-09-30 Impact factor: 4.813
Authors: Iris K Rüssel; Wessel P Brouwer; Tjeerd Germans; Paul Knaapen; J Tim Marcus; Jolanda van der Velden; Marco J W Götte; Albert C van Rossum Journal: J Cardiovasc Magn Reson Date: 2011-01-10 Impact factor: 5.364