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Literature DB >> 14745078

White matter lesions and hippocampal atrophy in Alzheimer's disease.

Frank-Erik de Leeuw¹, Frederik Barkhof, Philip Scheltens.

Abstract

White matter lesions (WML) and hippocampal atrophy (HA) on MRI commonly co-occur in Alzheimer's disease (AD) and are thought to play a role in the etiology of AD. It is still not known whether WML and HA are independent or related. The authors investigated the relation between WML and HA in 179 patients with probable AD who had a cerebral MRI. A linear relation was found between WML and HA, especially for WML in the frontal and parieto-occipital regions. The results suggest that vascular pathology and typical AD pathology (HA) are related.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 14745078 DOI： 10.1212/01.wnl.0000103289.03648.ad

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

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Cited

27 in total

1. Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.

Authors: T M Polvikoski; E C W van Straaten; F Barkhof; R Sulkava; H J Aronen; L Niinistö; M Oinas; P Scheltens; T Erkinjuntti; R N Kalaria
Journal: Neurology Date: 2010-11-03 Impact factor: 9.910

2. Diffusion tensor imaging of the hippocampus and verbal memory performance: the RUN DMC study.

Authors: Anouk G W van Norden; Karlijn F de Laat; Ilma Fick; Inge W M van Uden; Lucas J B van Oudheusden; Rob A R Gons; David G Norris; Marcel P Zwiers; Roy P C Kessels; Frank-Erik de Leeuw
Journal: Hum Brain Mapp Date: 2011-03-09 Impact factor: 5.038

3. Decreased oligodendrocyte nuclear diameter in Alzheimer's disease and Lewy body dementia.

Authors: Eva Gagyi; Bernadett Kormos; Karla J Castellanos; Klara Valyi-Nagy; Dennis Korneff; Patrizia LoPresti; Randy Woltjer; Tibor Valyi-Nagy
Journal: Brain Pathol Date: 2012-04-12 Impact factor: 6.508

4. Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls.

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Review 5. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.

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Journal: Hypertension Date: 2016-10-10 Impact factor: 10.190

6. Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression.

Authors: Joost Janssen; Hilleke E Hulshoff Pol; Frank-Erik de Leeuw; Hugo G Schnack; Indrag K Lampe; Rob M Kok; Rene S Kahn; Thea J Heeren
Journal: J Neurol Neurosurg Psychiatry Date: 2007-01-08 Impact factor: 10.154

7. Diffusion tensor imaging of the hippocampus predicts the risk of dementia; the RUN DMC study.

Authors: I W M van Uden; A M Tuladhar; H M van der Holst; E M C van Leijsen; A G W van Norden; K F de Laat; L C A Rutten-Jacobs; D G Norris; J A H R Claassen; E J van Dijk; R P C Kessels; F-E de Leeuw
Journal: Hum Brain Mapp Date: 2015-10-15 Impact factor: 5.038