Literature DB >> 14744094

From functional genomics to systems biology: concepts and practices.

Charles Auffray1, Sandrine Imbeaud, Magali Roux-Rouquié, Leroy Hood.   

Abstract

Systems biology is the iterative and integrative study of biological systems as systems in response to perturbations. It is founded on hypotheses formalized in models built from the results of global functional genomics analyses of the complexity of the genome, transcriptome, proteome, metabolome, etc. Its implementation by cross-disciplinary teams in a standardized mode under quality assurance should allow accessing the small variations of the large number of elements determining functioning of biological systems. Galactose utilization in yeast, and sea urchin development are two examples of emerging systems biology.

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Year:  2003        PMID： 14744094     DOI： 10.1016/j.crvi.2003.09.033

Source DB:  PubMed          Journal:  C R Biol        ISSN： 1631-0691            Impact factor:   1.583


  25 in total

1.  Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches.

Authors:  Maureen A O'Malley; Karola Stotz
Journal:  Philos Ethics Humanit Med       Date:  2011-01-28       Impact factor: 2.464

Review 2.  New hyphenated methodologies in high-sensitivity glycoprotein analysis.

Authors:  Milos V Novotny; Yehia Mechref
Journal:  J Sep Sci       Date:  2005-10       Impact factor: 3.645

3.  Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition.

Authors:  Sonia S Hassan; Roberto Romero; Adi L Tarca; Sorin Draghici; Beth Pineles; Andrej Bugrim; Nahla Khalek; Natalia Camacho; Pooja Mittal; Bo Hyun Yoon; Jimmy Espinoza; Chong Jai Kim; Yoram Sorokin; John Malone
Journal:  Am J Obstet Gynecol       Date:  2007-09       Impact factor: 8.661

Review 4.  Proteomic approaches and identification of novel therapeutic targets for alcoholism.

Authors:  Giorgio Gorini; R Adron Harris; R Dayne Mayfield
Journal:  Neuropsychopharmacology       Date:  2013-07-31       Impact factor: 7.853

5.  Convergent Lines of Descent: Symptoms, Patterns, Constellations, and the Emergent Interface of Systems Biology and Chinese Medicine.

Authors:  Volker Scheid
Journal:  East Asian Sci Technol Soc       Date:  2014-03-01

6.  The University of Washington Health Sciences Library BioCommons: an evolving Northwest biomedical research information support infrastructure.

Authors:  Mark Minie; Stuart Bowers; Peter Tarczy-Hornoch; Edward Roberts; Rose A James; Neil Rambo; Sherrilynne Fuller
Journal:  J Med Libr Assoc       Date:  2006-07

7.  Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human.

Authors:  Kyoko Kojima; Gregory J Bowersock; Chinatsu Kojima; Christopher A Klug; William E Grizzle; James A Mobley
Journal:  Proteomics       Date:  2012-11       Impact factor: 3.984

Review 8.  What does physics have to do with cancer?

Authors:  Franziska Michor; Jan Liphardt; Mauro Ferrari; Jonathan Widom
Journal:  Nat Rev Cancer       Date:  2011-08-18       Impact factor: 60.716

9.  Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis.

Authors:  Vincenza Pace; Dina Bellizzi; Francesca Giordano; Maria Luisa Panno; Giovanna De Benedictis
Journal:  Cell Stress Chaperones       Date:  2009-05-20       Impact factor: 3.667

10.  Systems medicine: the future of medical genomics and healthcare.

Authors:  Charles Auffray; Zhu Chen; Leroy Hood
Journal:  Genome Med       Date:  2009-01-20       Impact factor: 11.117
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