Literature DB >> 14742220

Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057.

E Limburg1, R Gahlmann, H-P Kroll, D Beyer.   

Abstract

TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.

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Year:  2004        PMID： 14742220      PMCID： PMC321526          DOI： 10.1128/AAC.48.2.619-622.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  TAN-1057A: a translational inhibitor with a specific inhibitory effect on 50S ribosomal subunit formation.

Authors:  W S Champney; J Pelt; C L Tober
Journal:  Curr Microbiol       Date:  2001-11       Impact factor: 2.188

Review 2.  Bacterial ribosomal subunit synthesis: a novel antibiotic target.

Authors:  W S Champney
Journal:  Curr Drug Targets Infect Disord       Date:  2001-05

3.  Staphylococcus aureus cell extract transcription-translation assay: firefly luciferase reporter system for evaluating protein translation inhibitors.

Authors:  R W Murray; E P Melchior; J C Hagadorn; K R Marotti
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

4.  Novel antibiotics for the treatment of gram-positive bacterial infections.

Authors:  Michael Brands; Rainer Endermann; Reinhold Gahlmann; Jochen Krüger; Siegfried Raddatz; Jürgen Stoltefuss; Vladimir N Belov; Shamil Nizamov; Viktor V Sokolov; Armin de Meijere
Journal:  J Med Chem       Date:  2002-09-12       Impact factor: 7.446

5.  Ribosomes from an oxazolidinone-resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free transcription-translation assay.

Authors:  R W Murray; R D Schaadt; G E Zurenko; K R Marotti
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

Review 6.  Mechanisms of action of antimicrobials: focus on fluoroquinolones.

Authors:  D C Hooper
Journal:  Clin Infect Dis       Date:  2001-03-15       Impact factor: 9.079

7.  Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.

Authors:  J Prystowsky; F Siddiqui; J Chosay; D L Shinabarger; J Millichap; L R Peterson; G A Noskin
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

8.  Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors:  L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

Review 9.  Resistance mechanisms of gram-positive bacteria.

Authors:  Brigitte Berger-Bächi
Journal:  Int J Med Microbiol       Date:  2002-06       Impact factor: 3.473

10.  Characterization of a novel antibacterial agent that inhibits bacterial translation.

Authors:  Nina Böddeker; Gina Bahador; Craig Gibbs; Eric Mabery; John Wolf; Lianhong Xu; Julia Watson
Journal:  RNA       Date:  2002-09       Impact factor: 4.942
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