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Literature DB >> 14742219

fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol.

Abstract

The Staphylococcus lentus plasmid pSCFS2 carries a novel florfenicol-chloramphenicol resistance gene, designated fexA, encoding a protein of 475 amino acids with 14 transmembrane domains. The FexA protein differs from all previously known proteins involved in the efflux of chloramphenicol and florfenicol. Induction of fexA expression by chloramphenicol and florfenicol occurs via translational attenuation.

Entities: Chemical Species

Mesh：

Substances：

Year: 2004 PMID： 14742219 PMCID： PMC321516 DOI： 10.1128/AAC.48.2.615-618.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

Review 1. Use of antimicrobials in veterinary medicine and mechanisms of resistance.

Authors: S Schwarz; E Chaslus-Dancla
Journal: Vet Res Date: 2001 May-Aug Impact factor: 3.683

2. Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A).

Authors: Stefan Schwarz; Corinna Kehrenberg; Kayode K Ojo
Journal: Antimicrob Agents Chemother Date: 2002-11 Impact factor: 5.191

Review 3. Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius.

Authors: C Werckenthin; M Cardoso; J L Martel; S Schwarz
Journal: Vet Res Date: 2001 May-Aug Impact factor: 3.683

4. Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn1696 integron suggests regulation by translational attenuation.

Authors: H W Stokes; R M Hall
Journal: Plasmid Date: 1991-07 Impact factor: 3.466

Review 5. Translational attenuation as the regulator of inducible cat genes.

Authors: P S Lovett
Journal: J Bacteriol Date: 1990-01 Impact factor: 3.490

Review 6. O-Acetyltransferases for chloramphenicol and other natural products.

Authors: I A Murray; W V Shaw
Journal: Antimicrob Agents Chemother Date: 1997-01 Impact factor: 5.191

Review 7. Antimicrobial resistance of Staphylococcus aureus: genetic basis.

Authors: B R Lyon; R Skurray
Journal: Microbiol Rev Date: 1987-03

8. Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors: M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
Journal: Lancet Date: 2001-04-21 Impact factor: 79.321

9. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri.

Authors: S Schwarz; C Werckenthin; C Kehrenberg
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

10. Nucleotide sequence and phylogeny of a chloramphenicol acetyltransferase encoded by the plasmid pSCS7 from Staphylococcus aureus.

Authors: S Schwarz; M Cardoso
Journal: Antimicrob Agents Chemother Date: 1991-08 Impact factor: 5.191

30 in total

1. Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid.

Authors: Kevin S Lang; Jessica L Danzeisen; Wayne Xu; Timothy J Johnson
Journal: Appl Environ Microbiol Date: 2012-02-17 Impact factor: 4.792

2. Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics.

Authors: Kevin S Lang; Janet M Anderson; Stefan Schwarz; Lynn Williamson; Jo Handelsman; Randall S Singer
Journal: Appl Environ Microbiol Date: 2010-06-11 Impact factor: 4.792

3. First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces.

Authors: Lei Dai; Cong-Ming Wu; Ming-Gui Wang; Yang Wang; Yu Wang; Si-Yang Huang; Li-Ning Xia; Bei-Bei Li; Jian-Zhong Shen
Journal: Antimicrob Agents Chemother Date: 2010-06-28 Impact factor: 5.191

4. A novel fexA variant from a canine Staphylococcus pseudintermedius isolate that does not confer florfenicol resistance.

Authors: Elena Gómez-Sanz; Kristina Kadlec; Andrea T Feßler; Myriam Zarazaga; Carmen Torres; Stefan Schwarz
Journal: Antimicrob Agents Chemother Date: 2013-08-26 Impact factor: 5.191

Review 5. Efflux-mediated drug resistance in bacteria: an update.

Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2009-08-20 Impact factor: 9.546

6. The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics.

Authors: Katherine S Long; Jacob Poehlsgaard; Corinna Kehrenberg; Stefan Schwarz; Birte Vester
Journal: Antimicrob Agents Chemother Date: 2006-07 Impact factor: 5.191