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Literature DB >> 20543056

Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics.

Kevin S Lang¹, Janet M Anderson, Stefan Schwarz, Lynn Williamson, Jo Handelsman, Randall S Singer.

Abstract

Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily.

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 20543056 PMCID： PMC2916469 DOI： 10.1128/AEM.00323-10

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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9. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota.

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