Literature DB >> 14741570

Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system.

Zhonglin Liu1, Gail D Stevenson, Harrison H Barrett, George A Kastis, Michael Bettan, Lars R Furenlid, Donald W Wilson, James M Woolfenden.   

Abstract

Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

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Year:  2004        PMID： 14741570      PMCID： PMC3062994          DOI： 10.1016/s0969-8051(03)00119-7

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  41 in total

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Authors:  W T Bellamy
Journal:  Annu Rev Pharmacol Toxicol       Date:  1996       Impact factor: 13.820

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Journal:  Am J Med       Date:  1995-12-29       Impact factor: 4.965

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Authors:  S Del Vecchio; A Ciarmiello; M Salvatore
Journal:  Cancer Biother Radiopharm       Date:  2000-08       Impact factor: 3.099

4.  In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients.

Authors:  S D Vecchio; A Ciarmiello; M I Potena; M V Carriero; C Mainolfi; G Botti; R Thomas; M Cerra; G D'Aiuto; T Tsuruo; M Salvatore
Journal:  Eur J Nucl Med       Date:  1997-02

5.  Myocardial technetium-99m-tetrofosmin and technetium-99m-sestamibi kinetics in normal subjects and patients with coronary artery disease.

Authors:  G Münch; J Neverve; I Matsunari; G Schröter; M Schwaiger
Journal:  J Nucl Med       Date:  1997-03       Impact factor: 10.057

6.  Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation.

Authors:  D Piwnica-Worms; V V Rao; J F Kronauge; J M Croop
Journal:  Biochemistry       Date:  1995-09-26       Impact factor: 3.162

7.  Uptake of technetium-99m-tetrofosmin, technetium-99m-MIBI and thallium-201 in tumor cell lines.

Authors:  A S Arbab; K Koizumi; K Toyama; T Araki
Journal:  J Nucl Med       Date:  1996-09       Impact factor: 10.057

8.  Technetium-99m-tetrofosmin as a substrate for P-glycoprotein: in vitro studies in multidrug-resistant breast tumor cells.

Authors:  J R Ballinger; J Bannerman; I Boxen; P Firby; N G Hartman; M J Moore
Journal:  J Nucl Med       Date:  1996-09       Impact factor: 10.057

Review 9.  The genetic basis of resistance to cancer chemotherapy.

Authors:  J R Woodhouse; D R Ferry
Journal:  Ann Med       Date:  1995-04       Impact factor: 4.709

10.  99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance: in vitro and in vivo studies in a rat breast tumour cell line and its doxorubicin-resistant variant.

Authors:  J R Ballinger; H A Hua; B W Berry; P Firby; I Boxen
Journal:  Nucl Med Commun       Date:  1995-04       Impact factor: 1.690
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  11 in total

1.  64Cu-labeled 2-(diphenylphosphoryl)ethyldiphenylphosphonium cations as highly selective tumor imaging agents: effects of linkers and chelates on radiotracer biodistribution characteristics.

Authors:  Chang-Tong Yang; Young-Seung Kim; Jianjun Wang; Lijun Wang; Jiyun Shi; Zi-Bo Li; Xiaoyuan Chen; Ming Fan; Jian-Jian Li; Shuang Liu
Journal:  Bioconjug Chem       Date:  2008-09-03       Impact factor: 4.774

2.  Tumor hypoxia imaging.

Authors:  Xilin Sun; Gang Niu; Nicholas Chan; Baozhong Shen; Xiaoyuan Chen
Journal:  Mol Imaging Biol       Date:  2011-06       Impact factor: 3.488

Review 3.  64Cu-labeled phosphonium cations as PET radiotracers for tumor imaging.

Authors:  Yang Zhou; Shuang Liu
Journal:  Bioconjug Chem       Date:  2011-07-01       Impact factor: 4.774

4.  Nude mice multi-drug resistance model of orthotopic transplantation of liver neoplasm and Tc-99m MIBI SPECT on p-glycoprotein.

Authors:  Yu Han; Xiao-Ping Chen; Zhi-Yong Huang; Hong Zhu
Journal:  World J Gastroenterol       Date:  2005-06-14       Impact factor: 5.742

5.  Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin.

Authors:  Zhonglin Liu; Gail D Stevenson; Harrison H Barrett; Lars R Furenlid; Donald W Wilson; George A Kastis; Michael Bettan; James M Woolfenden
Journal:  Nucl Med Biol       Date:  2005-08       Impact factor: 2.408

6.  Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes.

Authors:  Marco Fellner; Wolfgang Dillenburg; Hans-Georg Buchholz; Nicole Bausbacher; Mathias Schreckenberger; Franz Renz; Frank Rösch; Oliver Thews
Journal:  Mol Imaging Biol       Date:  2011-10       Impact factor: 3.488

7.  Mechanism for myocardial localization and rapid liver clearance of Tc-99m-N-MPO: a new perfusion radiotracer for heart imaging.

Authors:  Young-Seung Kim; Jiyun Shi; Shizhen Zhai; Guihua Hou; Shuang Liu
Journal:  J Nucl Cardiol       Date:  2009-03-14       Impact factor: 5.952

8.  Evaluation of (64)Cu(DO3A-xy-TPEP) as a potential PET radiotracer for monitoring tumor multidrug resistance.

Authors:  Shuang Liu; Young-Seung Kim; Shizhen Zhai; Jiyun Shi; Guihua Hou
Journal:  Bioconjug Chem       Date:  2009-04       Impact factor: 4.774

9.  Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

Authors:  Fijs W B van Leeuwen; Tessa Buckle; Ariena Kersbergen; Sven Rottenberg; Kenneth G A Gilhuijs
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-12-18       Impact factor: 9.236

10.  The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT.

Authors:  Dan Ma; Paul Wolf; Anne V Clough; Taly Gilat Schmidt
Journal:  IEEE Trans Nucl Sci       Date:  2013-02       Impact factor: 1.679
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