| Literature DB >> 14741295 |
William G Harter1, Hans Albrect, Kenneth Brady, Bradley Caprathe, James Dunbar, John Gilmore, Sheryl Hays, Catherine R Kostlan, Beth Lunney, Nigel Walker.
Abstract
A series of sulfonamides (1) has been prepared as inhibitors of interleukin-1beta converting enzyme (ICE), also known as caspase 1. These compounds were designed to improve potency by rigidifying the enzyme bound molecule through an intramolecular hydrogen bond. An X-ray crystal structure of a representative member of this series bound to the active site of ICE, confirms the presence of the hydrogen bonding interaction.Entities:
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Year: 2004 PMID： 14741295 DOI： 10.1016/j.bmcl.2003.10.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823