| Literature DB >> 14741294 |
Yongxin Han1, André Giroux, Erich L Grimm, Renée Aspiotis, Sébastien Francoeur, Christopher I Bayly, Daniel J Mckay, Sophie Roy, Steve Xanthoudakis, John P Vaillancourt, Dita M Rasper, John Tam, Paul Tawa, Nancy A Thornberry, Erin P Paterson, Margarita Garcia-Calvo, Joseph W Becker, Jennifer Rotonda, Donald W Nicholson, Robert J Zamboni.
Abstract
The discovery of a series of potent, selective and reversible dipeptidyl caspase-3 inhibitors are reported. The iterative discovery process of using combinatorial chemistry, parallel synthesis, moleculare modelling and structural biology will be discussed.Entities:
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Year: 2004 PMID： 14741294 DOI： 10.1016/j.bmcl.2003.10.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823