| Literature DB >> 14741282 |
Taiwei Chu1, Shaowen Hu, Bing Wei, Yi Wang, Xinqi Liu, Xiangyun Wang.
Abstract
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N4IPA) was synthesized. The biodistribution of 99mTc-N4IPA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that 99mTc-N4IPA would be a marker for imaging tumor hypoxia.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14741282 DOI： 10.1016/j.bmcl.2003.11.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823