Literature DB >> 14740053

An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.

Jaim S Oliveira1, Eduardo H S Sousa, Luiz A Basso, Moisés Palaci, Reynaldo Dietze, Diógenes S Santos, Icaro S Moreira.   

Abstract

The in vitro kinetics of inactivation of both wild-type and I21V InhA enzymes by [FeII(CN)5(INH)]3- indicate that this process requires no activation by KatG, and no need for the presence of NADH. This inorganic complex may represent a new class of lead compounds to the development of anti-tubercular agents aiming at inhibition of a validated target.

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Year:  2004        PMID： 14740053     DOI： 10.1039/b313592f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

Authors:  Eduardo Henrique Silva Sousa; Luiz Augusto Basso; Diógenes S Santos; Izaura Cirino Nogueira Diógenes; Elisane Longhinotti; Luiz Gonzaga de França Lopes; Icaro de Sousa Moreira
Journal:  J Biol Inorg Chem       Date:  2011-09-28       Impact factor: 3.358

2.  Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex: a molecular dynamics simulation study.

Authors:  André L P da Costa; Ivani Pauli; Márcio Dorn; Evelyn K Schroeder; Chang-Guo Zhan; Osmar Norberto de Souza
Journal:  J Mol Model       Date:  2011-08-12       Impact factor: 1.810

Review 3.  Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

Authors:  Pan Pan; Peter J Tonge
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

4.  Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Authors:  Bruno L Abbadi; Anne D Villela; Valnês S Rodrigues-Junior; Fernanda T Subtil; Pedro F Dalberto; Ana P S Pinheiro; Diógenes S Santos; Pablo Machado; Luiz A Basso; Cristiano V Bizarro
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

5.  Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP.

Authors:  Guy Barros Barcellos; Rafael Andrade Caceres; Walter Filgueira de Azevedo
Journal:  J Mol Model       Date:  2008-11-29       Impact factor: 1.810

6.  Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex.

Authors:  Patrícia Soares de Maria de Medeiros; Rodrigo Gay Ducati; Luiz Augusto Basso; Diógenes Santiago Santos; Luiz Hildebrando Pereira da Silva
Journal:  Enzyme Res       Date:  2011-03-22

7.  Mining flexible-receptor docking experiments to select promising protein receptor snapshots.

Authors:  Karina S Machado; Ana T Winck; Duncan D A Ruiz; Osmar Norberto de Souza
Journal:  BMC Genomics       Date:  2010-12-22       Impact factor: 3.969

8.  FReDoWS: a method to automate molecular docking simulations with explicit receptor flexibility and snapshots selection.

Authors:  Karina S Machado; Evelyn K Schroeder; Duncan D Ruiz; Elisângela M L Cohen; Osmar Norberto de Souza
Journal:  BMC Genomics       Date:  2011-12-22       Impact factor: 3.969

9.  Effect of the explicit flexibility of the InhA enzyme from Mycobacterium tuberculosis in molecular docking simulations.

Authors:  Elisangela M L Cohen; Karina S Machado; Marcelo Cohen; Osmar Norberto de Souza
Journal:  BMC Genomics       Date:  2011-12-22       Impact factor: 3.969

10.  Automatic design of decision-tree induction algorithms tailored to flexible-receptor docking data.

Authors:  Rodrigo C Barros; Ana T Winck; Karina S Machado; Márcio P Basgalupp; André C P L F de Carvalho; Duncan D Ruiz; Osmar Norberto de Souza
Journal:  BMC Bioinformatics       Date:  2012-11-21       Impact factor: 3.169
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