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Literature DB >> 14738966

In vitro study of some medicinally important Mannich bases derived from antitubercular agent.

Sheela Joshi¹, Navita Khosla, Prapti Tiwari.

Abstract

Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.

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Year: 2004 PMID： 14738966 DOI： 10.1016/j.bmc.2003.11.001

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

14 in total

1. 4-(4-Bromo-benzyl-ideneamino)-3-{1-[4-(2-methyl-prop-yl)phen-yl]eth-yl}-1-(mor-phol-ino-meth-yl)-1H-1,2,4-triazole-5(4H)-thione.

Authors: Hoong-Kun Fun; Samuel Robinson Jebas; P S Patil; B Kalluraya; A Muralidharan
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2008-07-23

2. 3-{1-[4-(2-Methyl-prop-yl)phen-yl]eth-yl}-1-(morpholinometh-yl)-4-(4-nitro-benzyl-ideneamino)-1H-1,2,4-triazole-5(4H)-thione.

Authors: Hoong-Kun Fun; Suchada Chantrapromma; K V Sujith; B Kalluraya
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2009-02-11

3. An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions.

Authors: Bushra Nisar; Syeda Laila Rubab; Abdul Rauf Raza; Sobia Tariq; Ayesha Sultan; Muhammad Nawaz Tahir
Journal: Mol Divers Date: 2018-04-11 Impact factor: 2.943

10. Design, synthesis, characterization, and computational studies on benzamide substituted Mannich bases as novel, potential antibacterial agents.

Authors: Suman Bala; Neha Sharma; Anu Kajal; Sunil Kamboj
Journal: ScientificWorldJournal Date: 2014-01-19

In vitro study of some medicinally important Mannich bases derived from antitubercular agent.

1. 4-(4-Bromo-benzyl-ideneamino)-3-{1-[4-(2-methyl-prop-yl)phen-yl]eth-yl}-1-(mor-phol-ino-meth-yl)-1H-1,2,4-triazole-5(4H)-thione.

2. 3-{1-[4-(2-Methyl-prop-yl)phen-yl]eth-yl}-1-(morpholinometh-yl)-4-(4-nitro-benzyl-ideneamino)-1H-1,2,4-triazole-5(4H)-thione.

3. An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions.

Review 4. Mannich bases in medicinal chemistry and drug design.

5. 1-(2-Benzoyl-1-phenyl-eth-yl)-4-[(2-hy-droxy-1-naphth-yl)methyl-idene-amino]-3-methyl-1H-1,2,4-triazole-5(4H)-thione.

6. 4-{(E)-[2-(4-Iodo-but-oxy)benzyl-idene]amino}-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

7. 1-(2-Benzoyl-1-phenyl-eth-yl)-4-[(2-hy-droxy-1-naphth-yl)methyl-idene-amino]-3-phenyl-1H-1,2,4-triazole-5(4H)-thione.

8. Studies on the anthelmintic property of aminobenzylated mannich bases.

Review 9. Mannich bases: an important pharmacophore in present scenario.

10. Design, synthesis, characterization, and computational studies on benzamide substituted Mannich bases as novel, potential antibacterial agents.