| Literature DB >> 14738383 |
Ademar A da Silva Filho1, Sérgio Albuquerque, Márcio L A e Silva, Marcos N Eberlin, Daniela M Tomazela, Jairo K Bastos.
Abstract
The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC(50) value of 2.2 microM and lysis of 94% of the parasites at 32 microM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.Entities:
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Year: 2004 PMID： 14738383 DOI： 10.1021/np0302697
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050