Literature DB >> 14737674

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways.

Edward M Rosser1, Simon Morton, Kate S Ashton, Philip Cohen, Alison N Hulme.   

Abstract

The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

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Year:  2003        PMID： 14737674     DOI： 10.1039/b311242j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

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