Literature DB >> 1473583

Potentiation of antifungal activity of sesquiterpene dialdehydes against Candida albicans and two other fungi.

I Kubo1, M Himejima.   

Abstract

The antifungal activity of two drimane sesquiterpene dialdehydes, polygodial (1) and warburganal (2), alone and in combination with several other substances, was examined against three fungi, Candida albicans, Saccharomyces cerevisiae and Pityrosporum ovale employing a broth dilution method. Anethole significantly synergized the activity of the two sesquiterpenoids against C. albicans and S. cerevisiae; however, it had only an additive effect against P. ovale. By contrast, two antioxidants, ascorbic acid (vitamin C) and BHA (butylated hydroxyanisole), noticeably enhanced the activity of the sesquiterpenoids against P. ovale, but had no effect against C. albicans and S. cerevisiae.

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Year:  1992        PMID： 1473583     DOI： 10.1007/bf01948015

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

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Authors:  R F McCallion; A L Cole; J R Walker; J W Blunt; M H Munro
Journal:  Planta Med       Date:  1982-03       Impact factor: 3.352

4.  Polygodial, an antifungal potentiator.

Authors:  I Kubo; M Taniguchi
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  4 in total
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9.  Optimising Terpene Synthesis with Flow Biocatalysis.

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