Literature DB >> 1473580

Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice.

M Ishikawa1, M Ozaki, Y Takayanagi, K Sasaki.   

Abstract

The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1473580     DOI： 10.1007/bf01948009

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists.

Authors:  J S Lazo; W N Hait; K A Kennedy; I D Braun; B Meandzija
Journal:  Mol Pharmacol       Date:  1985-03       Impact factor: 4.436

2.  Micro scale. Rapid and simple determination of tegafur (FT) by high pressure liquid chromatography in plasma.

Authors:  M Ishikawa; M Sasaki; K Sasaki; Y Takayanagi
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1989-05

3.  Inhibitory effects of calmodulin antagonists on urinary enzyme excretion in rats after nephrotoxic doses of mercuric chloride.

Authors:  S D Harrison; J L Cox; R C Giles
Journal:  Bull Environ Contam Toxicol       Date:  1985-03       Impact factor: 2.151

4.  Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

Authors:  W C Prozialeck; B Weiss
Journal:  J Pharmacol Exp Ther       Date:  1982-09       Impact factor: 4.030

5.  Effect of nitrosoureas on calmodulin activity in vitro and in mouse intestine in vivo.

Authors:  S D Harrison; D M Mann; R C Giles
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

6.  A comparison of the antiemetic efficacy of prochlorperazine and metoclopramide for the treatment of cisplatin-induced emesis: a prospective, randomized, double-blind study.

Authors:  B I Carr; M Bertrand; S Browning; J H Doroshow; C Presant; B Pulone; L R Hill
Journal:  J Clin Oncol       Date:  1985-08       Impact factor: 44.544

7.  Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.

Authors:  R Ganapathi; D Grabowski
Journal:  Cancer Res       Date:  1983-08       Impact factor: 12.701

8.  Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

Authors:  T Tsuruo; H Iida; S Tsukagoshi; Y Sakurai
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

9.  Effects of prochlorperazine on experimental nephrotoxicity.

Authors:  S D Harrison; J L Cox; R C Giles
Journal:  Cancer Chemother Pharmacol       Date:  1982-12       Impact factor: 3.333

Review 10.  Biochemical modulation of cisplatin toxicity.

Authors:  R F Borch; M Markman
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.