Literature DB >> 1473559

5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle.

J Lorrain1, A Grosset, S E O'Connor.   

Abstract

Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by the 5-HT4 receptor antagonist, SDZ 205-557, with a pA2 of 7.3. In contrast to atrial tissues, piglet papillary muscles were virtually unresponsive to 5-HT 10(-8)-10(-3) M, suggesting that functional cardiac 5-HT4 receptors are not present in ventricular tissue.

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Year:  1992        PMID： 1473559     DOI： 10.1016/0014-2999(92)90293-d

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium.

Authors:  Alberto J Kaumann; Finn Olav Levy
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

2.  The guinea-pig distal colon--a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions.

Authors:  K A Wardle; G J Sanger
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

3.  Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.

Authors:  Joris H De Maeyer; Roel Straetemans; Jan A J Schuurkes; Romain A Lefebvre
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

4.  Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186.

Authors:  S G Parker; E M Taylor; S A Hamburger; M Vimal; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

5.  Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle.

Authors:  F S Tam; K Hillier; K T Bunce; C Grossman
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

6.  Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.

Authors:  Trond Brattelid; Eirik Qvigstad; James A Lynham; Peter Molenaar; Halfdan Aass; Odd Geiran; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy; Alberto J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-09-07       Impact factor: 3.000
  6 in total

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