Literature DB >> 16331292

Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium.

Alberto J Kaumann1, Finn Olav Levy.   

Abstract

Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated responses to 5-HT and the partial agonist prucalopride in porcine atrium.

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Year:  2006        PMID： 16331292      PMCID： PMC1615854          DOI： 10.1038/sj.bjp.0706501

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  24 in total

1.  Cardiovascular effects of intravenous infusions of 5-hydroxytryptamine in man.

Authors:  D H LEMESSURIER; C J SCHWARTZ; R F WHELAN
Journal:  Br J Pharmacol Chemother       Date:  1959-06

2.  Comparison of the densities of 5-HT4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications.

Authors:  A J Kaumann; J A Lynham; A M Brown
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-04       Impact factor: 3.000

3.  Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure.

Authors:  Eirik Qvigstad; Trond Brattelid; Ivar Sjaastad; Kjetil Wessel Andressen; Kurt A Krobert; Jon Arne Birkeland; Ole M Sejersted; Alberto J Kaumann; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy
Journal:  Cardiovasc Res       Date:  2005-03-01       Impact factor: 10.787

4.  Labelling with [125I]-SB 207710 of a small 5-HT4 receptor population in piglet right atrium: functional relevance.

Authors:  A J Kaumann; J A Lynham; A M Brown
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

5.  Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.

Authors:  Joris H De Maeyer; Roel Straetemans; Jan A J Schuurkes; Romain A Lefebvre
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

6.  5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.

Authors:  T Bach; T Syversveen; A M Kvingedal; K A Krobert; T Brattelid; A J Kaumann; F O Levy
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2001-02       Impact factor: 3.000

7.  Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186.

Authors:  S G Parker; E M Taylor; S A Hamburger; M Vimal; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

8.  A 5-hydroxytryptamine receptor in human atrium.

Authors:  A J Kaumann; L Sanders; A M Brown; K J Murray; M J Brown
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

9.  Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium.

Authors:  Maria Jesús Juan-Fita; Maria Luisa Vargas; Alberto J Kaumann; Jesus Hernández Cascales
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-09-25       Impact factor: 3.000

10.  Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.

Authors:  Trond Brattelid; Eirik Qvigstad; James A Lynham; Peter Molenaar; Halfdan Aass; Odd Geiran; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy; Alberto J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-09-07       Impact factor: 3.000
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  3 in total

1.  5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.

Authors:  F Afzal; K W Andressen; H K Mørk; J M Aronsen; I Sjaastad; C P Dahl; T Skomedal; F O Levy; J-B Osnes; E Qvigstad
Journal:  Br J Pharmacol       Date:  2008-09-01       Impact factor: 8.739

2.  Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.

Authors:  Alejandro Galindo-Tovar; Maria Luisa Vargas; Elisa Escudero; Alberto J Kaumann
Journal:  Br J Pharmacol       Date:  2009-01-19       Impact factor: 8.739

3.  Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.

Authors:  Finn Olav Levy
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-05-07       Impact factor: 3.000
  3 in total

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