Literature DB >> 14734156

A comprehensive geriatric intervention detects multiple problems in older breast cancer patients.

Martine Extermann1, Julie Meyer, Margaret McGinnis, Theresa T Crocker, Mary Beth Corcoran, Jerry Yoder, William E Haley, Hongbin Chen, David Boulware, Lodovico Balducci.   

Abstract

UNLABELLED: Studies of comprehensive geriatric assessment (CGA) have shown the importance of follow-up for effectiveness, but this has not been tested in an oncology clinic. In this pilot study, we enrolled 15 early breast cancer patients, aged 70 and older. They received a multidisciplinary CGA every 3 months and structured follow-up from the SAOP nurse practitioner, dietitian, social worker, and pharmacist according to risk. Total follow-up was 6 months. Median age of evaluable patients was 79 years (range 72-87). Median number of comorbidities by Cumulative Index Rating Scale-Geriatric (CIRS-G) was 5 (3-9) at baseline. Ten patients were at pharmacological risk, five at psychosocial risk, and eight at nutritional risk. Patients presented on average six problems initially, and three new problems during follow-up. The intervention directly influenced oncological treatment in four cases. It ensured continuity/coordination of care in seven cases. Success rate in addressing problems was 87%. Mean Functional Assessment of Cancer Treatment-Breast (FACT-B) scores improved from 110.5 (S.D. 16.7) to 116.3 (S.D. 16.5) (t=0.025). Function and independence were maintained.
CONCLUSIONS: Older patients with early breast cancer have a high prevalence of comorbidity. A CGA with follow-up has potential for improving the treatment and prognosis of these patients and is feasible in an academic oncology setting.

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Year:  2004        PMID: 14734156     DOI: 10.1016/s1040-8428(03)00099-4

Source DB:  PubMed          Journal:  Crit Rev Oncol Hematol        ISSN: 1040-8428            Impact factor:   6.312


  41 in total

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2.  Translation Requires Evidence: Does Cancer-Specific CGA Lead to Better Care and Outcomes?

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4.  Assessment of health status in elderly patients with cancer.

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Journal:  Rep Pract Oncol Radiother       Date:  2012-08-09

5.  Comprehensive geriatric assessment in the older cancer patient: coming of age in clinical cancer care.

Authors:  Cynthia Owusu; Nathan A Berger
Journal:  Clin Pract (Lond)       Date:  2014

Review 6.  An update on cancer- and chemotherapy-related cognitive dysfunction: current status.

Authors:  Michelle C Janelsins; Sadhna Kohli; Supriya G Mohile; Kenneth Usuki; Tim A Ahles; Gary R Morrow
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7.  Using heat maps to assess the multidimensional association of comorbidities with survival in older cancer patients treated with chemotherapy.

Authors:  Jae Jin Lee; Jongphil Kim; Marina Sehovic; Lu Chen; Martine Extermann
Journal:  J Geriatr Oncol       Date:  2017-07-22       Impact factor: 3.599

8.  Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up.

Authors:  Kerri M Clough-Gorr; Andreas E Stuck; Soe Soe Thwin; Rebecca A Silliman
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9.  Impact of radiotherapy on the quality of life of elderly patients with localized breast cancer. A prospective study.

Authors:  Juan Ignacio Arraras; Ana Manterola; Miguel Angel Domínguez; Fernando Arias; Elena Villafranca; Pilar Romero; Enrique Martínez; José Juan Illarramendi; Esteban Salgado
Journal:  Clin Transl Oncol       Date:  2008-08       Impact factor: 3.405

10.  Frailty and adherence to adjuvant hormonal therapy in older women with breast cancer: CALGB protocol 369901.

Authors:  Vanessa B Sheppard; Leigh Anne Faul; George Luta; Jonathan D Clapp; Rachel L Yung; Judy Huei-Yu Wang; Gretchen Kimmick; Claudine Isaacs; Michelle Tallarico; William T Barry; Brandelyn N Pitcher; Clifford Hudis; Eric P Winer; Harvey J Cohen; Hyman B Muss; Arti Hurria; Jeanne S Mandelblatt
Journal:  J Clin Oncol       Date:  2014-06-16       Impact factor: 44.544

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