BACKGROUND: The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples. METHODS: We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18. RESULTS: We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4. CONCLUSIONS: Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
BACKGROUND: The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples. METHODS: We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18. RESULTS: We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4. CONCLUSIONS: Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
Authors: Wenhua Liu; Eunice Y Yuen; Patrick B Allen; Jian Feng; Paul Greengard; Zhen Yan Journal: Proc Natl Acad Sci U S A Date: 2006-11-13 Impact factor: 11.205
Authors: Marta de Castro-Catala; Paula Cristóbal-Narváez; Thomas R Kwapil; Tamara Sheinbaum; Elionora Peña; Neus Barrantes-Vidal; Araceli Rosa Journal: Eur Arch Psychiatry Clin Neurosci Date: 2016-02-24 Impact factor: 5.270
Authors: G Rivero; A M Gabilondo; J A García-Sevilla; L F Callado; R La Harpe; B Morentin; J J Meana Journal: Psychopharmacology (Berl) Date: 2012-10-24 Impact factor: 4.530
Authors: Jubao Duan; Maria Martinez; Alan R Sanders; Cuiping Hou; Naruya Saitou; Takashi Kitano; Bryan J Mowry; Raymond R Crowe; Jeremy M Silverman; Douglas F Levinson; Pablo V Gejman Journal: Am J Hum Genet Date: 2004-08-24 Impact factor: 11.025