| Literature DB >> 14732226 |
Wolfgang M Brueckl1, Elvira Heinze, Catrin Milsmann, Axel Wein, Corinna Koebnick, Andreas Jung, Roland S Croner, Thomas Brabletz, Klaus Günther, Thomas Kirchner, Eckhart G Hahn, Werner Hohenberger, Heinz Becker, Bertram Reingruber.
Abstract
Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-beta RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n=10) had a CSS of 49.6 months in contrast to patients with stable tumors (23.2 months) (P=0.010). Additionally, a low tumor stage according to UICC and MSI-H were shown to be independent factors (P=0.005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage.Entities:
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Year: 2004 PMID： 14732226 DOI： 10.1016/j.canlet.2003.08.013
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679