Literature DB >> 14729325

HTTM, a horizontally transferred transmembrane domain.

Jörg Schultz1.   

Abstract

Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members.

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Year:  2004        PMID： 14729325     DOI： 10.1016/j.tibs.2003.11.002

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  8 in total

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Authors:  Mark A Rishavy; Kathleen L Berkner
Journal:  Adv Nutr       Date:  2012-03-01       Impact factor: 8.701

2.  Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.

Authors:  Jan Claesen; Mervyn Bibb
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

3.  The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.

Authors:  Mark A Rishavy; Kevin W Hallgren; Kathleen L Berkner
Journal:  J Biol Chem       Date:  2011-09-06       Impact factor: 5.157

4.  More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.

Authors:  Wing-Cheong Wong; Sebastian Maurer-Stroh; Frank Eisenhaber
Journal:  PLoS Comput Biol       Date:  2010-07-29       Impact factor: 4.475

5.  Production of the cannibalism toxin SDP is a multistep process that requires SdpA and SdpB.

Authors:  Tiara G Pérez Morales; Theresa D Ho; Wei-Ting Liu; Pieter C Dorrestein; Craig D Ellermeier
Journal:  J Bacteriol       Date:  2013-05-17       Impact factor: 3.490

6.  Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of histidine 160 disrupts glutamic acid carbanion formation and efficient coupling of vitamin K epoxidation to glutamic acid carboxylation.

Authors:  Mark A Rishavy; Kathleen L Berkner
Journal:  Biochemistry       Date:  2008-08-22       Impact factor: 3.162

7.  Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins.

Authors:  Wing-Cheong Wong; Sebastian Maurer-Stroh; Frank Eisenhaber
Journal:  Biol Direct       Date:  2011-10-25       Impact factor: 4.540

Review 8.  GGCX-Associated Phenotypes: An Overview in Search of Genotype-Phenotype Correlations.

Authors:  Eva Y G De Vilder; Jens Debacker; Olivier M Vanakker
Journal:  Int J Mol Sci       Date:  2017-01-25       Impact factor: 5.923
  8 in total

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