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Literature DB >> 14728197

Functional relationships between gene pairs in oral squamous cell carcinoma.

Winston Patrick Kuo¹, Eduardo Mendez, Chu Chen, Mark E Whipple, Greg Farell, Nicholas Agoff, Peter J Park.

Abstract

We developed a novel method for the discovery of functional relationships between pairs of genes based on gene expression profiles generated from microarrays. This approach examines all possible pairs of genes and identifies those in which the relationship between the two genes changes in different diseases or conditions. In contrast to previous methods that have focused on differentially expressed genes, this method attempts to find changes in the correlation between genes. These changes may be indicative of the functional relationships related to a disease mechanism. We demonstrate the utility of this approach by applying it to an oral squamous cell carcinoma (OSCC) microarray data set. Our results suggest new directions for future experimental investigations.

Entities: Disease

Mesh：

Year: 2003 PMID： 14728197 PMCID： PMC1479982

Source DB: PubMed Journal: AMIA Annu Symp Proc ISSN： 1559-4076

8 in total

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Journal: Nat Genet Date: 2001-05 Impact factor: 38.330

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Authors: J Quackenbush
Journal: Nat Rev Genet Date: 2001-06 Impact factor: 53.242

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Authors: Winston Patrick Kuo; Tor-Kristian Jenssen; Peter J Park; Mark W Lingen; Rifat Hasina; Lucila Ohno-Machado
Journal: Proc AMIA Symp Date: 2002

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Authors: Eduardo Méndez; Chun Cheng; D Gregory Farwell; Sherianne Ricks; S Nicholas Agoff; Neal D Futran; Ernest A Weymuller; Nicole C Maronian; Lue Ping Zhao; Chu Chen
Journal: Cancer Date: 2002-10-01 Impact factor: 6.860

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Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

8 in total

4 in total

4. Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma.

Authors: Divya Sahu; Chia-Lang Hsu; Chen-Ching Lin; Tz-Wen Yang; Wen-Ming Hsu; Shinn-Ying Ho; Hsueh-Fen Juan; Hsuan-Cheng Huang
Journal: Oncotarget Date: 2016-09-06