| Literature DB >> 14727218 |
Mauro Zaccarelli1, Carlo Federico Perno, Federica Forbici, Fabio Soldani, Sandro Bonfigli, Caterina Gori, Maria Paola Trotta, Maria Concetta Bellocchi, Giuseppina Liuzzi, Roberta D'Arrigo, Patrizio De Longis, Evangelo Boumis, Rita Bellagamba, Valerio Tozzi, Pasquale Narciso, Andrea Antinori.
Abstract
Among 470 patients with acquired immune deficiency syndrome and/or human immunodeficiency virus infection (HIV/AIDS) who underwent genotype resistance testing (GRT) after the failure of therapy, 17 (3.6%) harbored the Q151M mutation. The Q151M mutation was associated with younger age, lower CD4(+) lymphocyte count, higher HIV RNA level, and treatment with >2 pre-GRT regimens. By contrast, the Q151M mutation was inversely associated with lamivudine administration. A full reversion of the Q151M mutation was observed in 5 of 5 patients who underwent treatment interruption after GRT. The reversion was followed by a response to salvage therapy in 4 (80%) of 5 patients.Entities:
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Year: 2004 PMID： 14727218 DOI： 10.1086/381097
Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079