Literature DB >> 14727185

The use of CpG as an adjuvant to Toxoplasma gondii vaccination.

Jennifer A Spencer1, Bruce F Smith, Anthony J Guarino, Byron L Blagburn, Henry J Baker.   

Abstract

Unmethylated CpG dinucleotides have been found to stimulate general immune responses in mammals. CpG motifs have further been shown to be potent adjuvants when used in conjunction with vaccines for viral and bacterial organisms. It was necessary to determine whether these CpG motifs will also enhance immune responses in parasitic diseases. We therefore decided to test the effect of CpG adjuventation on immunization with a temperature-sensitive mutant (ts4) strain of Toxoplasma gondii. Mice were divided into groups receiving either ts4 only, CpG only, ts4 with CpG, or untreated controls. Mice were challenged with a lethal dose of T. gondii (RH strain) tachyzoites 28 days after vaccination. There were significant differences observed between the ts4-only group and the other three groups with regards to antibody isotype and survival, with the former group surviving lethal challenge. CpG adjuventation appeared to not enhance survival.

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Year:  2004        PMID： 14727185     DOI： 10.1007/s00436-003-1039-7

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  23 in total

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Authors:  I A Khan; L Casciotti
Journal:  J Immunol       Date:  1999-10-15       Impact factor: 5.422

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Authors:  L C Gavrilescu; E Y Denkers
Journal:  J Immunol       Date:  2001-07-15       Impact factor: 5.422

3.  Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

Authors:  R T Gazzinelli; F T Hakim; S Hieny; G M Shearer; A Sher
Journal:  J Immunol       Date:  1991-01-01       Impact factor: 5.422

4.  Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria.

Authors:  K L Elkins; T R Rhinehart-Jones; S Stibitz; J S Conover; D M Klinman
Journal:  J Immunol       Date:  1999-02-15       Impact factor: 5.422

5.  Activation of human B cells by phosphorothioate oligodeoxynucleotides.

Authors:  H Liang; Y Nishioka; C F Reich; D S Pisetsky; P E Lipsky
Journal:  J Clin Invest       Date:  1996-09-01       Impact factor: 14.808

6.  Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12.

Authors:  J H Chace; N A Hooker; K L Mildenstein; A M Krieg; J S Cowdery
Journal:  Clin Immunol Immunopathol       Date:  1997-08

7.  Functional and quantitative analysis of splenic T cell immune responses following oral toxoplasma gondii infection in mice.

Authors:  Y H Lee; J Y Channon; T Matsuura; J D Schwartzman; D W Shin; L H Kasper
Journal:  Exp Parasitol       Date:  1999-03       Impact factor: 2.011

8.  Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.

Authors:  T R Jones; N Obaldia; R A Gramzinski; Y Charoenvit; N Kolodny; S Kitov; H L Davis; A M Krieg; S L Hoffman
Journal:  Vaccine       Date:  1999-08-06       Impact factor: 3.641

9.  Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice.

Authors:  Alberto Fachado; Alexandro Rodriguez; Sergio O Angel; Diamar C Pinto; Iviane Vila; Armando Acosta; Regina R Amendoeira; Joseli Lannes-Vieira
Journal:  Vaccine       Date:  2003-03-28       Impact factor: 3.641

10.  Live and killed vaccines against toxoplasmosis in mice.

Authors:  H Waldeland; J K Frenkel
Journal:  J Parasitol       Date:  1983-02       Impact factor: 1.276
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  5 in total

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Journal:  J Parasit Dis       Date:  2014-09-05

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Authors:  Sonaimuthu Parthasarathy; Mun Yik Fong; Kalyanasundaram Ramaswamy; Yee Ling Lau
Journal:  Am J Trop Med Hyg       Date:  2013-03-18       Impact factor: 2.345

3.  A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models.

Authors:  Hayam Mohamed Ezz Eldin; Hanan Hussein Kamel; Abeer Fathy Badawy; Lobna Sadek Shash
Journal:  J Parasit Dis       Date:  2013-11-20

Review 4.  Toxoplasma rhoptries: unique secretory organelles and source of promising vaccine proteins for immunoprevention of toxoplasmosis.

Authors:  Henryka Dlugonska
Journal:  J Biomed Biotechnol       Date:  2008

5.  Evaluation of Immunogenic Effect of Toxoplasma gondii Recombinant SAG-1 Antigen with Propranolol as Adjuvant in BALB/c Mice.

Authors:  Esmaeil Abasi; Shahram Shahabi; Majid Golkar; Peyman Khezri; Habib Mohammadzadeh Hajipirloo
Journal:  Adv Pharm Bull       Date:  2019-10-24
  5 in total

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