| Literature DB >> 14726226 |
Zeki Yildirim1, Süleyman Hacievliyagil, Nurettin Onur Kutlu, Nasuhi Engin Aydin, Mine Kurkcuoglu, Mustafa Iraz, Riza Durmaz.
Abstract
Mycobacterium tuberculosis (H(37)R(v))-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid (n=5) or saline (n=6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P>0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P>0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model.Entities:
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Year: 2004 PMID： 14726226 DOI： 10.1016/j.phrs.2003.10.007
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658