| Literature DB >> 14719923 |
Michael C Pirrung1, Koushik Das Sarma.
Abstract
Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries.Entities:
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Year: 2004 PMID： 14719923 DOI： 10.1021/ja038583a
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419