Literature DB >> 14715445

Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway.

Silvia Mandel1, Lydia Reznichenko, Tamar Amit, Moussa B H Youdim.   

Abstract

Our recent studies have demonstrated that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective/neurorescue effects against B-amyloid toxicity and protects neuronal cells from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (MPP+) and 6-hydroxydopamine in vitro, or from N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced nigral dopaminergic neuronal loss in mice. In the present study, we report that EGCG (0.1 and 1 microM) significantly protects rat pheochromocytoma PC12 cells from apoptosis induced by serum support withdrawal, suggesting that EGCG may play a role in the growth of PC12 cells, where it stimulates survival-promoting pathways.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14715445     DOI： 10.1007/bf03033171

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  13 in total

Review 1.  Apoptosis in neural development and disease.

Authors:  D Nijhawan; N Honarpour; X Wang
Journal:  Annu Rev Neurosci       Date:  2000       Impact factor: 12.449

2.  Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells.

Authors:  N K Huang; Y W Lin; C L Huang; R O Messing; Y Chern
Journal:  J Biol Chem       Date:  2001-01-29       Impact factor: 5.157

3.  Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures.

Authors:  Yona Levites; Moussa B H Youdim; Gila Maor; Silvia Mandel
Journal:  Biochem Pharmacol       Date:  2002-01-01       Impact factor: 5.858

4.  Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death.

Authors:  C Chen; R Yu; E D Owuor; A N Kong
Journal:  Arch Pharm Res       Date:  2000-12       Impact factor: 4.946

5.  Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration.

Authors:  Y Levites; O Weinreb; G Maor; M B Youdim; S Mandel
Journal:  J Neurochem       Date:  2001-09       Impact factor: 5.372

Review 6.  Neurotrophin signal transduction in the nervous system.

Authors:  D R Kaplan; F D Miller
Journal:  Curr Opin Neurobiol       Date:  2000-06       Impact factor: 6.627

7.  Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils.

Authors:  S Lee; S Suh; S Kim
Journal:  Neurosci Lett       Date:  2000-06-30       Impact factor: 3.046

8.  Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin.

Authors:  Orly Weinreb; Silvia Mandel; Moussa B H Youdim
Journal:  Ann N Y Acad Sci       Date:  2003-05       Impact factor: 5.691

9.  Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action.

Authors:  Yona Levites; Tamar Amit; Moussa B H Youdim; Silvia Mandel
Journal:  J Biol Chem       Date:  2002-06-10       Impact factor: 5.157

10.  Ameliorative effects of tea catechins on active oxygen-related nerve cell injuries.

Authors:  Y Matsuoka; H Hasegawa; S Okuda; T Muraki; T Uruno; K Kubota
Journal:  J Pharmacol Exp Ther       Date:  1995-08       Impact factor: 4.030
View more
  16 in total

1.  Involvement of α7 nAChR signaling cascade in epigallocatechin gallate suppression of β-amyloid-induced apoptotic cortical neuronal insults.

Authors:  Xijing Zhang; Mingmei Wu; Fan Lu; Na Luo; Zu-Ping He; Hao Yang
Journal:  Mol Neurobiol       Date:  2013-06-27       Impact factor: 5.590

2.  Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties.

Authors:  Orly Weinreb; Tamar Amit; Silvia Mandel; Moussa B H Youdim
Journal:  Genes Nutr       Date:  2009-09-10       Impact factor: 5.523

3.  Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship.

Authors:  Felicia Rivera; Jessika Urbanavicius; Elena Gervaz; Andrea Morquio; Federico Dajas
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

Review 4.  Neurotoxins and neurotoxic species implicated in neurodegeneration.

Authors:  Juan Segura Aguilar; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

5.  Neuroprotective properties of Valeriana officinalis extracts.

Authors:  João O Malva; Sandra Santos; Tice Macedo
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

6.  Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion.

Authors:  C R Creveling
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

Review 7.  Nutrition and the risk for Parkinson's disease: review of the literature.

Authors:  Alexandra Gaenslen; Thomas Gasser; Daniela Berg
Journal:  J Neural Transm (Vienna)       Date:  2008-01-11       Impact factor: 3.575

8.  Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway.

Authors:  Qinyong Ye; Linfeng Ye; Xianjie Xu; Bixia Huang; Xiaodong Zhang; Yuangui Zhu; Xiaochun Chen
Journal:  BMC Complement Altern Med       Date:  2012-06-28       Impact factor: 3.659

9.  Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death.

Authors:  Masoumeh Akhlaghi; Brian Bandy
Journal:  Oxid Med Cell Longev       Date:  2012-07-05       Impact factor: 6.543

Review 10.  Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.

Authors:  Richard M Kostrzewa; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.978
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.