Literature DB >> 14715431

Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion.

C R Creveling1.   

Abstract

Recent genetic epidemiological studies implicate a low activity form of catechol-O-methyltransferase (COMT) with increased risk factor for breast cancer. Taking into account, the role of COMT in the metabolism of otherwise carcinogenic catecholestrogens, it is reasonable to propose that environmental or dietary products that inhibit COMT pose a risk for breast cancer.

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Year:  2003        PMID： 14715431     DOI： 10.1007/bf03033157

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  10 in total

1.  Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.

Authors:  P A Thompson; P G Shields; J L Freudenheim; A Stone; J E Vena; J R Marshall; S Graham; R Laughlin; T Nemoto; F F Kadlubar; C B Ambrosone
Journal:  Cancer Res       Date:  1998-05-15       Impact factor: 12.701

2.  Nuclear localization of catechol-O-methyltransferase in neoplastic and nonneoplastic mammary epithelial cells.

Authors:  J Weisz; G Fritz-Wolz; S Gestl; G A Clawson; C R Creveling; J G Liehr; D Dabbs
Journal:  Am J Pathol       Date:  2000-06       Impact factor: 4.307

Review 3.  Estrogens as endogenous genotoxic agents--DNA adducts and mutations.

Authors:  E Cavalieri; K Frenkel; J G Liehr; E Rogan; D Roy
Journal:  J Natl Cancer Inst Monogr       Date:  2000

Review 4.  Wine and resveratrol: mechanisms of cancer prevention?

Authors:  F Bianchini; H Vainio
Journal:  Eur J Cancer Prev       Date:  2003-10       Impact factor: 2.497

5.  Hypothesis: is antibiotic use associated with breast cancer?

Authors:  Christine M Velicer; Johanna W Lampe; Susan R Heckbert; John D Potter; Stephen H Taplin
Journal:  Cancer Causes Control       Date:  2003-10       Impact factor: 2.506

6.  Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.

Authors:  H Adlercreutz; H Honjo; A Higashi; T Fotsis; E Hämäläinen; T Hasegawa; H Okada
Journal:  Am J Clin Nutr       Date:  1991-12       Impact factor: 7.045

7.  The relationship between alcohol use and risk of breast cancer by histology and hormone receptor status among women 65-79 years of age.

Authors:  Christopher I Li; Kathleen E Malone; Peggy L Porter; Noel S Weiss; Mei-Tzu C Tang; Janet R Daling
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2003-10       Impact factor: 4.254

8.  Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway.

Authors:  Silvia Mandel; Lydia Reznichenko; Tamar Amit; Moussa B H Youdim
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

9.  Cell culture protection and in vivo neuroprotective capacity of flavonoids.

Authors:  Federico Dajas; Felicia Rivera; Fernanda Blasina; Florencia Arredondo; Carolina Echeverry; Laura Lafon; Andrea Morquio; Horacio Heinzen; Horacio Heizen
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

10.  Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

Authors:  R M Weinshilboum; F A Raymond
Journal:  Am J Hum Genet       Date:  1977-03       Impact factor: 11.025
  10 in total
  2 in total

1.  Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.

Authors:  Samantha F Butts; Ellen W Freeman; Mary D Sammel; Kaila Queen; Hui Lin; Timothy R Rebbeck
Journal:  J Clin Endocrinol Metab       Date:  2012-03-30       Impact factor: 5.958

2.  A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).

Authors:  L T Roten; M H Fenstad; S Forsmo; M P Johnson; E K Moses; R Austgulen; F Skorpen
Journal:  Mol Hum Reprod       Date:  2011-02-25       Impact factor: 4.025
  2 in total

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