Literature DB >> 14714177

Ultrastructural and cytochemical identification of megasome in Leishmania (Leishmania) chagasi.

Sanny O Alberio1, Suzana S Dias, Flávio P Faria, Renato A Mortara, Clara L Barbiéri, Edna Freymüller Haapalainen.   

Abstract

The present work showed the presence of a megasome in Leishmania (Leishmania) chagasi amastigotes. Transmission electron microscopy analysis of ultrathin serial sections and three-dimensional reconstruction allowed visualization of large structures in amastigote forms of L. (L.) chagasi and a multivesicular tubule-lysosome structure in metacyclic promastigotes. Morphometric data showed that the relative volume occupied by the megasome and the multivesicular tubule (MVT)-lysosome structures was about 5% and 3.2%, respectively, in amastigotes and promastigotes of L. (L.) chagasi. Further characterization of the megasome in L. (L.) chagasi amastigotes was carried out by immunolabeling of cysteine proteinase, whereas the lysosomal content of amastigotes and promastigotes was confirmed by arylsulfatase cytochemistry.

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Year:  2004        PMID： 14714177     DOI： 10.1007/s00436-003-1027-y

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  25 in total

1.  Trafficking of cysteine proteinase to Leishmania lysosomes: lack of involvement of glycosylation.

Authors:  L K Boukai; D da Costa-Pinto; M J Soares; D McMahon-Pratt; Y M Traub-Cseko
Journal:  Mol Biochem Parasitol       Date:  2000-04-15       Impact factor: 1.759

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Journal:  J Protozool       Date:  1975-11

3.  Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana.

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Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

4.  Leishmania mexicana: amastigote hydrolases in unusual lysosomes.

Authors:  M F Pupkis; L Tetley; G H Coombs
Journal:  Exp Parasitol       Date:  1986-08       Impact factor: 2.011

5.  Inhibition of Leishmania amastigote growth by antipain and leupeptin.

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Journal:  Ann Trop Med Parasitol       Date:  1984-02

6.  The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases.

Authors:  S M Duboise; M A Vannier-Santos; D Costa-Pinto; L Rivas; A A Pan; Y Traub-Cseko; W De Souza; D McMahon-Pratt
Journal:  Mol Biochem Parasitol       Date:  1994-11       Impact factor: 1.759

7.  Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction.

Authors:  Y M Traub-Cseko; M Duboise; L K Boukai; D McMahon-Pratt
Journal:  Mol Biochem Parasitol       Date:  1993-01       Impact factor: 1.759

Review 8.  Developmental changes in lysosome morphology and function Leishmania parasites.

Authors:  Ross F Waller; Malcolm J McConville
Journal:  Int J Parasitol       Date:  2002-11       Impact factor: 3.981

9.  Three dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial sections.

Authors:  G H Coombs; L Tetley; V A Moss; K Vickerman
Journal:  Parasitology       Date:  1986-02       Impact factor: 3.234

10.  Processing and trafficking of cysteine proteases in Leishmania mexicana.

Authors:  D R Brooks; L Tetley; G H Coombs; J C Mottram
Journal:  J Cell Sci       Date:  2000-11       Impact factor: 5.285
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  4 in total

1.  Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium.

Authors:  Tatiana Shioji Tiuman; Tânia Ueda-Nakamura; Diógenes Aparício Garcia Cortez; Benedito Prado Dias Filho; José Andrés Morgado-Díaz; Wanderley de Souza; Celso Vataru Nakamura
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

2.  Serine protease activities in Leishmania (Leishmania) chagasi promastigotes.

Authors:  Raquel Elisa da Silva-López; Tatiana Resende dos Santos; José Andrés Morgado-Díaz; Marcelo Neves Tanaka; Salvatore Giovanni de Simone
Journal:  Parasitol Res       Date:  2010-07-29       Impact factor: 2.289

3.  Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes.

Authors:  Daniel Paape; Christoph Lippuner; Monika Schmid; Renate Ackermann; Martin E Barrios-Llerena; Ursula Zimny-Arndt; Volker Brinkmann; Benjamin Arndt; Klaus Peter Pleissner; Peter R Jungblut; Toni Aebischer
Journal:  Mol Cell Proteomics       Date:  2008-05-12       Impact factor: 5.911

4.  In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences.

Authors:  Marieke Vermeersch; Raquel Inocêncio da Luz; Kim Toté; Jean-Pierre Timmermans; Paul Cos; Louis Maes
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191
  4 in total

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