Literature DB >> 14714102

Effects of MDMA (ecstasy), and multiple drugs use on (simulated) driving performance and traffic safety.

Karel A Brookhuis1, Dick de Waard, Nele Samyn.   

Abstract

RATIONALE: The effects of MDMA on driving behaviour are not clear, since the direct effects of MDMA on cognitive performance are reported as not generally negative.
OBJECTIVES: To assess in an advanced driving simulator acute effects on simulated driving behaviour and heart rate of MDMA, and effects of polydrug use.
METHODS: A group of young participants who had indicated that they regularly used MDMA were asked to complete test rides in an advanced driving simulator, shortly after the use of MDMA, just before going to a party. They were tested again after having visited the "rave", while they were under the influence of MDMA and a number of different other active drugs. Participants were also tested sober, at a comparable time at night. Separately, a control group of participants was included in the experiment.
RESULTS: Driving performance in the sense of lateral and longitudinal vehicle control was not greatly affected after MDMA, but deteriorated after multiple drug use. The most striking result was the apparent decreased sense for risk taking, both after MDMA and after multiple drug use. This was clear from gap acceptance data, while the ultimate indicator of unsafe driving, accident involvement or even causation, was increased by 100% and 150%, respectively.
CONCLUSIONS: Driving under the influence of MDMA alone is certainly not safe; however, driving back (home) after a dance party ("rave") where MDMA users regularly combine MDMA with a host of other drugs can be described as extremely dangerous.

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Year:  2004        PMID: 14714102     DOI: 10.1007/s00213-003-1714-5

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN: 0033-3158            Impact factor:   4.530


  18 in total

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Authors:  L J Mulder
Journal:  Biol Psychol       Date:  1992-11       Impact factor: 3.251

Review 2.  Analysis of Drugs in Saliva.

Authors:  N Samyn; A Verstraete; C van Haeren; P Kintz
Journal:  Forensic Sci Rev       Date:  1999-06

3.  3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) and driving impairment.

Authors:  B K Logan; F J Couper
Journal:  J Forensic Sci       Date:  2001-11       Impact factor: 1.832

4.  Cognitive performance and serotonergic function in users of ecstasy.

Authors:  R J Verkes; H J Gijsman; M S Pieters; R C Schoemaker; S de Visser; M Kuijpers; E J Pennings; D de Bruin; G Van de Wijngaart; J M Van Gerven; A F Cohen
Journal:  Psychopharmacology (Berl)       Date:  2001-01-01       Impact factor: 4.530

5.  Metabolic and cardiorespiratory measures of mental effort: the effects of level of difficulty in a working memory task.

Authors:  R W Backs; K A Seljos
Journal:  Int J Psychophysiol       Date:  1994-02       Impact factor: 2.997

6.  Cannabis use and traffic accidents in a birth cohort of young adults.

Authors:  D M Fergusson; L J Horwood
Journal:  Accid Anal Prev       Date:  2001-11

7.  Recreational use of "ecstasy" (MDMA) is associated with elevated impulsivity.

Authors:  M J Morgan
Journal:  Neuropsychopharmacology       Date:  1998-10       Impact factor: 7.853

8.  Acute and subchronic effects of the H1-histamine receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance.

Authors:  K A Brookhuis; G De Vries; D De Waard
Journal:  Br J Clin Pharmacol       Date:  1993-07       Impact factor: 4.335

9.  Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?

Authors:  J H Krystal; L H Price; C Opsahl; G A Ricaurte; G R Heninger
Journal:  Am J Drug Alcohol Abuse       Date:  1992       Impact factor: 3.829

10.  Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance.

Authors:  A C Parrott; J Lasky
Journal:  Psychopharmacology (Berl)       Date:  1998-10       Impact factor: 4.530

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  15 in total

1.  Risky car following in abstinent users of MDMA.

Authors:  Elizabeth Dastrup; Monica N Lees; Antoine Bechara; Jeffrey D Dawson; Matthew Rizzo
Journal:  Accid Anal Prev       Date:  2010-05

2.  The effects of dexamphetamine on simulated driving performance.

Authors:  B Y Silber; K Papafotiou; R J Croft; E Ogden; P Swann; C Stough
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3.  Effects of alcohol hangover on simulated highway driving performance.

Authors:  Joris C Verster; Adriana C Bervoets; Suzanne de Klerk; Rick A Vreman; Berend Olivier; Thomas Roth; Karel A Brookhuis
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4.  MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function.

Authors:  K P C Kuypers; N Samyn; J G Ramaekers
Journal:  Psychopharmacology (Berl)       Date:  2006-07-08       Impact factor: 4.530

5.  Polysubstance use profiles among electronic dance music party attendees in New York City and their relation to use of new psychoactive substances.

Authors:  Fermín Fernández-Calderón; Charles M Cleland; Joseph J Palamar
Journal:  Addict Behav       Date:  2017-11-04       Impact factor: 3.913

6.  The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI).

Authors:  Shahaf Edut; Vardit Rubovitch; Shaul Schreiber; Chaim G Pick
Journal:  Psychopharmacology (Berl)       Date:  2010-12-01       Impact factor: 4.530

7.  A European study on alcohol and drug use among young drivers: the TEND by Night study design and methodology.

Authors:  Roberta Siliquini; Simone Chiadò Piat; Francisco Alonso; Axel Druart; Marcin Kedzia; Antonio Mollica; Valeria Siliquini; Daniel Vankov; Anita Villerusa; Lamberto Manzoli
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8.  The effect of d,l-methamphetamine on simulated driving performance.

Authors:  Beata Y Silber; Rodney J Croft; Luke A Downey; David A Camfield; Katherine Papafotiou; Phillip Swann; Con Stough
Journal:  Psychopharmacology (Berl)       Date:  2011-08-13       Impact factor: 4.530

9.  Effects of alcohol (BAC 0.5‰) and ecstasy (MDMA 100 mg) on simulated driving performance and traffic safety.

Authors:  Janet L Veldstra; Karel A Brookhuis; Dick de Waard; Barbara H W Molmans; Alain G Verstraete; Gisela Skopp; Ricarda Jantos
Journal:  Psychopharmacology (Berl)       Date:  2011-11-11       Impact factor: 4.530

10.  Correlation between driving-related skill and alcohol use in young-adults from six European countries: the TEN-D by Night Project.

Authors:  Roberta Siliquini; Fabrizio Bert; Francisco Alonso; Paola Berchialla; Alessandra Colombo; Axel Druart; Marcin Kedzia; Valeria Siliquini; Daniel Vankov; Anita Villerusa; Lamberto Manzoli
Journal:  BMC Public Health       Date:  2011-07-01       Impact factor: 3.295

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