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Literature DB >> 14712352

From gene function to improved health: genome research in the United Kingdom.

Abstract

The United Kingdom has a prestigious track record in genetic and genomic research, with the structure of DNA, and delivery of a third of the human genome being significant landmarks. UK genomic research benefits from a variety of funding sources in both the public and private sector, and efforts to co-ordinate research strategies. Here we describe how this investment has impacted on the UK research capacity and highlight examples of progress in translating genetic information into improved healthcare.

Entities: Species

Mesh：

Year: 2004 PMID： 14712352 DOI： 10.1007/s00109-003-0516-x

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

17 in total

1. Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood.

Authors: Alexandra Trouton; Frank M Spinath; Robert Plomin
Journal: Twin Res Date: 2002-10

2. Association of malaria parasite population structure, HLA, and immunological antagonism.

Authors: S C Gilbert; M Plebanski; S Gupta; J Morris; M Cox; M Aidoo; D Kwiatkowski; B M Greenwood; H C Whittle; A V Hill
Journal: Science Date: 1998-02-20 Impact factor: 47.728

3. A forkhead-domain gene is mutated in a severe speech and language disorder.

Authors: C S Lai; S E Fisher; J A Hurst; F Vargha-Khadem; A P Monaco
Journal: Nature Date: 2001-10-04 Impact factor: 49.962

4. FOXP2 is not a major susceptibility gene for autism or specific language impairment.

Authors: D F Newbury; E Bonora; J A Lamb; S E Fisher; C S L Lai; G Baird; L Jannoun; V Slonims; C M Stott; M J Merricks; P F Bolton; A J Bailey; A P Monaco
Journal: Am J Hum Genet Date: 2002-03-13 Impact factor: 11.025

Review 5. Cancer susceptibility and the functions of BRCA1 and BRCA2.

Authors: Ashok R Venkitaraman
Journal: Cell Date: 2002-01-25 Impact factor: 41.582

6. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Authors: Avshalom Caspi; Karen Sugden; Terrie E Moffitt; Alan Taylor; Ian W Craig; HonaLee Harrington; Joseph McClay; Jonathan Mill; Judy Martin; Antony Braithwaite; Richie Poulton
Journal: Science Date: 2003-07-18 Impact factor: 47.728

7. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.

Authors: Paul Van Eerdewegh; Randall D Little; Josée Dupuis; Richard G Del Mastro; Kathy Falls; Jason Simon; Dana Torrey; Sunil Pandit; Joyce McKenny; Karen Braunschweiger; Alison Walsh; Ziying Liu; Brooke Hayward; Colleen Folz; Susan P Manning; Alicia Bawa; Lisa Saracino; Michelle Thackston; Youssef Benchekroun; Neva Capparell; Mei Wang; Ron Adair; Yun Feng; JoAnn Dubois; Michael G FitzGerald; Hui Huang; René Gibson; Kristina M Allen; Alex Pedan; Melvyn R Danzig; Shelby P Umland; Robert W Egan; Francis M Cuss; Steuart Rorke; Joanne B Clough; John W Holloway; Stephen T Holgate; Tim P Keith
Journal: Nature Date: 2002-07-10 Impact factor: 49.962

8. Mutations of the BRAF gene in human cancer.

Authors: Helen Davies; Graham R Bignell; Charles Cox; Philip Stephens; Sarah Edkins; Sheila Clegg; Jon Teague; Hayley Woffendin; Mathew J Garnett; William Bottomley; Neil Davis; Ed Dicks; Rebecca Ewing; Yvonne Floyd; Kristian Gray; Sarah Hall; Rachel Hawes; Jaime Hughes; Vivian Kosmidou; Andrew Menzies; Catherine Mould; Adrian Parker; Claire Stevens; Stephen Watt; Steven Hooper; Rebecca Wilson; Hiran Jayatilake; Barry A Gusterson; Colin Cooper; Janet Shipley; Darren Hargrave; Katherine Pritchard-Jones; Norman Maitland; Georgia Chenevix-Trench; Gregory J Riggins; Darell D Bigner; Giuseppe Palmieri; Antonio Cossu; Adrienne Flanagan; Andrew Nicholson; Judy W C Ho; Suet Y Leung; Siu T Yuen; Barbara L Weber; Hilliard F Seigler; Timothy L Darrow; Hugh Paterson; Richard Marais; Christopher J Marshall; Richard Wooster; Michael R Stratton; P Andrew Futreal
Journal: Nature Date: 2002-06-09 Impact factor: 49.962

9. A database for mouse development.

Authors: M Ringwald; R Baldock; J Bard; M Kaufman; J T Eppig; J E Richardson; J H Nadeau; D Davidson
Journal: Science Date: 1994-09-30 Impact factor: 47.728

10. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Authors: I Sadaf Farooqi; Giuseppe Matarese; Graham M Lord; Julia M Keogh; Elizabeth Lawrence; Chizo Agwu; Veronica Sanna; Susan A Jebb; Francesco Perna; Silvia Fontana; Robert I Lechler; Alex M DePaoli; Stephen O'Rahilly
Journal: J Clin Invest Date: 2002-10 Impact factor: 14.808

1 in total

1. Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options.

Authors: Rositsa Koleva-Kolarova; James Buchanan; Heleen Vellekoop; Simone Huygens; Matthijs Versteegh; Maureen Rutten-van Mölken; László Szilberhorn; Tamás Zelei; Balázs Nagy; Sarah Wordsworth; Apostolos Tsiachristas
Journal: Appl Health Econ Health Policy Date: 2022-04-04 Impact factor: 3.686

1 in total