Literature DB >> 11832208

Cancer susceptibility and the functions of BRCA1 and BRCA2.

Ashok R Venkitaraman1.   

Abstract

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Their ubiquitously expressed protein products are implicated in processes fundamental to all cells, including DNA repair and recombination, checkpoint control of cell cycle, and transcription. Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11832208     DOI： 10.1016/s0092-8674(02)00615-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  510 in total

1.  Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.

Authors:  Kumar Somyajit; Shreelakshmi Subramanya; Ganesh Nagaraju
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

Review 2.  Triple-negative breast cancer: present challenges and new perspectives.

Authors:  Franca Podo; Lutgarde M C Buydens; Hadassa Degani; Riet Hilhorst; Edda Klipp; Ingrid S Gribbestad; Sabine Van Huffel; Hanneke W M van Laarhoven; Jan Luts; Daniel Monleon; Geert J Postma; Nicole Schneiderhan-Marra; Filippo Santoro; Hans Wouters; Hege G Russnes; Therese Sørlie; Elda Tagliabue; Anne-Lise Børresen-Dale
Journal:  Mol Oncol       Date:  2010-04-24       Impact factor: 6.603

3.  Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage.

Authors:  Jeanho Yun; Wen-Hwa Lee
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

4.  A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.

Authors:  Nicolas Foray; Didier Marot; Anastasia Gabriel; Voahangy Randrianarison; Antony M Carr; Michel Perricaudet; Alan Ashworth; Penny Jeggo
Journal:  EMBO J       Date:  2003-06-02       Impact factor: 11.598

5.  A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.

Authors:  Amom Ruhikanta Meetei; Salvatore Sechi; Michael Wallisch; Dafeng Yang; Mary K Young; Hans Joenje; Maureen E Hoatlin; Weidong Wang
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

Review 6.  From gene function to improved health: genome research in the United Kingdom.

Authors:  George K Radda; Ian Viney
Journal:  J Mol Med (Berl)       Date:  2004-01-08       Impact factor: 4.599

7.  Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

Authors:  Liu Cao; Wenmei Li; Sangsoo Kim; Steven G Brodie; Chu-Xia Deng
Journal:  Genes Dev       Date:  2003-01-15       Impact factor: 11.361

8.  Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.

Authors:  Mikhail Lomonosov; Shubha Anand; Mahesh Sangrithi; Rachel Davies; Ashok R Venkitaraman
Journal:  Genes Dev       Date:  2003-12-17       Impact factor: 11.361

9.  Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.

Authors:  Sang Soo Kim; Liu Cao; Cuiling Li; Xiaoling Xu; L Julie Huber; Lewis A Chodosh; Chu-Xia Deng
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

10.  Unique tissue-specific level of DNA nucleotide excision repair in primary human mammary epithelial cultures.

Authors:  Jean J Latimer; Tariq Nazir; Lisa C Flowers; Michael J Forlenza; Kelly Beaudry-Rodgers; Crystal M Kelly; Julie A Conte; Kenneth Shestak; Amal Kanbour-Shakir; Stephen G Grant
Journal:  Exp Cell Res       Date:  2003-11-15       Impact factor: 3.905
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.