OBJECTIVE: To characterize the early stages of meiosis in a male with unexplained azoospermia. DESIGN: Case report. SETTING: Case Western Reserve University and University Hospitals of Cleveland. PATIENT(S): A 30-year-old male with nonobstructive azoospermia. INTERVENTION(S): Immunostaining for components of the synaptonemal complex and recombination-associated proteins, fluorescence in situ hybridization (FISH) for specific chromosomes. MAIN OUTCOME MEASURE(S): Progression to and through pachytene of meiosis I in controls and in the patient. RESULT(S): We observed complete meiosis I arrest in the patient, associated with failure of formation of the mature, tripartite synaptonemal complex. CONCLUSION(S): Abnormalities in synaptonemal complex formation are responsible for a proportion of cases of unexplained male infertility.
OBJECTIVE: To characterize the early stages of meiosis in a male with unexplained azoospermia. DESIGN: Case report. SETTING: Case Western Reserve University and University Hospitals of Cleveland. PATIENT(S): A 30-year-old male with nonobstructive azoospermia. INTERVENTION(S): Immunostaining for components of the synaptonemal complex and recombination-associated proteins, fluorescence in situ hybridization (FISH) for specific chromosomes. MAIN OUTCOME MEASURE(S): Progression to and through pachytene of meiosis I in controls and in the patient. RESULT(S): We observed complete meiosis I arrest in the patient, associated with failure of formation of the mature, tripartite synaptonemal complex. CONCLUSION(S): Abnormalities in synaptonemal complex formation are responsible for a proportion of cases of unexplained male infertility.
Authors: Petrice W Brown; Luann Judis; E Ricky Chan; Stuart Schwartz; Allen Seftel; Anthony Thomas; Terry J Hassold Journal: Am J Hum Genet Date: 2005-08-16 Impact factor: 11.025
Authors: Michelle L Lenzi; Jenetta Smith; Timothy Snowden; Mimi Kim; Richard Fishel; Bradford K Poulos; Paula E Cohen Journal: Am J Hum Genet Date: 2004-11-22 Impact factor: 11.025
Authors: M De Gregori; R Ciccone; P Magini; T Pramparo; S Gimelli; J Messa; F Novara; A Vetro; E Rossi; P Maraschio; M C Bonaglia; C Anichini; G B Ferrero; M Silengo; E Fazzi; A Zatterale; R Fischetto; C Previderé; S Belli; A Turci; G Calabrese; F Bernardi; E Meneghelli; M Riegel; M Rocchi; S Guerneri; F Lalatta; L Zelante; C Romano; M Fichera; T Mattina; G Arrigo; M Zollino; S Giglio; F Lonardo; A Bonfante; A Ferlini; F Cifuentes; H Van Esch; L Backx; A Schinzel; J R Vermeesch; O Zuffardi Journal: J Med Genet Date: 2007-08-31 Impact factor: 6.318