| Literature DB >> 14699462 |
Prema Gurumurthy1, Geetha Ramachandran, A K Hemanth Kumar, S Rajasekaran, C Padmapriyadarsini, Soumya Swaminathan, P Venkatesan, L Sekar, S Kumar, O R Krishnarajasekhar, P Paramesh.
Abstract
The absorption of rifampin, isoniazid, and D-xylose in patients with human immunodeficiency virus (HIV) infection and diarrhea, in patients with HIV infection and tuberculosis (TB), in patients with pulmonary TB alone, and in healthy subjects was studied. Percentage of dose of the drugs, their metabolites, and D-xylose excreted in urine were calculated. A significant reduction in the absorption of drugs and D-xylose in both the HIV infection/diarrhea and HIV infection/TB groups was observed (P<.05), and the correlation between them was significant. Our results indicate that patients with HIV infection and diarrhea and those with HIV infection and TB have malabsorption of rifampin and isoniazid.Entities:
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Year: 2003 PMID： 14699462 DOI： 10.1086/380795
Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079