| Literature DB >> 14694755 |
Alexandra C Provost1, Marie O Péquignot, Karine M Sainton, Stéphanie Gadin, Sandrine Sallé, Dominique Marchant, Dale B Hales, Marc Abitbol.
Abstract
The class-B type-I scavenger receptor (SR-BI) plays a key role in cholesterol homeostasis; it mediates the selective uptake of lipoprotein cholesterol to steroidogenic tissues. We show by RT-PCR, western blot, in situ hybridization and immunohistochemistry analysis that SR-BI is highly expressed in different neuro-retinal and non-neuronal cells types on rat eye. Immunohistochemistry of the steroidogenic acute regulatory protein (StAR) involved in neurosteroid production showed the same expression pattern than SR-BI in rat eye. Our results may suggest a key role of these genes in the ocular cholesterol metabolism for membranes biosynthesis and neurosteroidogenesis.Entities:
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Year: 2003 PMID： 14694755 DOI： 10.1016/j.crvi.2003.09.001
Source DB: PubMed Journal: C R Biol ISSN： 1631-0691 Impact factor: 1.583