Literature DB >> 14692747

Unraveling the mystery surrounding cholesterol's condensing effect.

Honghua Cao1, Nobuya Tokutake, Steven L Regen.   

Abstract

The results of nearest-neighbor recognition experiments that have been carried out with exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, in the presence of cholesterol, dihydrocholesterol, coprostanol, cholestane, cholesteryl methy ether, and sitosterol, provide strong support for a condensing mechanism in which the flexible acyl chains of the phospholipids complement, perfectly, the shape of neighboring sterols, thereby leading to a high number of hydrophobic contacts and tight packing.

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Year:  2003        PMID: 14692747     DOI: 10.1021/ja039172x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  12 in total

1.  Cholesterol-phospholipid association in fluid bilayers: a thermodynamic analysis from nearest-neighbor recognition measurements.

Authors:  Jianbing Zhang; Honghua Cao; Bingwen Jing; Paulo F Almeida; Steven L Regen
Journal:  Biophys J       Date:  2006-06-02       Impact factor: 4.033

2.  Ethanol-induced reorganization of the liquid-ordered phase: enhancement of cholesterol-phospholipid association.

Authors:  Jianbing Zhang; Honghua Cao; Bingwen Jing; Steven L Regen
Journal:  J Am Chem Soc       Date:  2006-01-11       Impact factor: 15.419

3.  Cholesterol-phospholipid complexation in fluid bilayers as evidenced by nearest-neighbor recognition measurements.

Authors:  Jianbing Zhang; Honghua Cao; Steven L Regen
Journal:  Langmuir       Date:  2007-01-16       Impact factor: 3.882

4.  The Effect of Cholesterol on the Dielectric Structure of Lipid Bilayers.

Authors:  Hadeel Alobeedallah; Bruce Cornell; Hans Coster
Journal:  J Membr Biol       Date:  2017-11-29       Impact factor: 1.843

5.  Solubility Limits of Cholesterol, Lanosterol, Ergosterol, Stigmasterol, and β-Sitosterol in Electroformed Lipid Vesicles.

Authors:  Mark M Stevens; Aurelia R Honerkamp-Smith; Sarah L Keller
Journal:  Soft Matter       Date:  2010-12-07       Impact factor: 3.679

6.  Sorting of lipidated peptides in fluid bilayers: a molecular-level investigation.

Authors:  Trevor A Daly; Paulo F Almeida; Steven L Regen
Journal:  J Am Chem Soc       Date:  2012-10-04       Impact factor: 15.419

7.  Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.

Authors:  Jay Liu; Catherine C Y Chang; Emily J Westover; Douglas F Covey; Ta-Yuan Chang
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

8.  Sterol structure determines miscibility versus melting transitions in lipid vesicles.

Authors:  Mary Elizabeth Beattie; Sarah L Veatch; Benjamin L Stottrup; Sarah L Keller
Journal:  Biophys J       Date:  2005-06-10       Impact factor: 4.033

9.  The origin of cholesterol's condensing effect.

Authors:  Trevor A Daly; Minghui Wang; Steven L Regen
Journal:  Langmuir       Date:  2011-02-14       Impact factor: 3.882

10.  Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase.

Authors:  Serhan Turkyilmaz; Paulo F Almeida; Steven L Regen
Journal:  Langmuir       Date:  2011-10-28       Impact factor: 3.882

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