Literature DB >> 1468572

Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast.

A L Glasser1, C el Adlouni, G Keith, E Sochacka, A Malkiewicz, M Santos, M F Tuite, J Desgrès.   

Abstract

The unknown modified nucleoside U* has been isolated by enzymatic and HPLC protocols from tRNA(Leu) (U*AA) recently discovered in brewer's yeast. The pure U* nucleoside has been characterized by electron impact mass spectroscopy, and comparison of its chromatographic and UV-absorption properties with those of appropriate synthetic compounds. The structure of U* was established as 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um). The yeast tRNA(Leu) (U*AA) is the only tRNA so far sequenced which has been shown to contain ncm5Um. The location of such a modified uridine at the first position of the anticodon restricts the decoding property to A of the leucine UUA codon.

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Year:  1992        PMID： 1468572     DOI： 10.1016/0014-5793(92)81510-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Effects of anticodon 2'-O-methylations on tRNA codon recognition in an Escherichia coli cell-free translation.

Authors:  A Satoh; K Takai; R Ouchi; S Yokoyama; H Takaku
Journal:  RNA       Date:  2000-05       Impact factor: 4.942

2.  Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast.

Authors:  Takayuki Ohira; Tsutomu Suzuki
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

3.  2'-O-methyl-5-formylcytidine (f5Cm), a new modified nucleotide at the 'wobble' of two cytoplasmic tRNAs Leu (NAA) from bovine liver.

Authors:  J P Païs de Barros; G Keith; C El Adlouni; A L Glasser; G Mack; G Dirheimer; J Desgrès
Journal:  Nucleic Acids Res       Date:  1996-04-15       Impact factor: 16.971

4.  An early step in wobble uridine tRNA modification requires the Elongator complex.

Authors:  Bo Huang; Marcus J O Johansson; Anders S Byström
Journal:  RNA       Date:  2005-04       Impact factor: 4.942

5.  Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.

Authors:  Lene Songe-Møller; Erwin van den Born; Vibeke Leihne; Cathrine B Vågbø; Terese Kristoffersen; Hans E Krokan; Finn Kirpekar; Pål Ø Falnes; Arne Klungland
Journal:  Mol Cell Biol       Date:  2010-02-01       Impact factor: 4.272

6.  The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes.

Authors:  Hasan Tükenmez; Hao Xu; Anders Esberg; Anders S Byström
Journal:  Nucleic Acids Res       Date:  2015-08-17       Impact factor: 16.971

7.  Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants.

Authors:  Changchun Chen; Simon Tuck; Anders S Byström
Journal:  PLoS Genet       Date:  2009-07-10       Impact factor: 5.917

8.  Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.

Authors:  Marcus J O Johansson; Anders Esberg; Bo Huang; Glenn R Björk; Anders S Byström
Journal:  Mol Cell Biol       Date:  2008-03-10       Impact factor: 4.272

9.  Toxicity of a heterologous leucyl-tRNA (anticodon CAG) in the pathogen Candida albicans: in vivo evidence for non-standard decoding of CUG codons.

Authors:  C E Leuker; J F Ernst
Journal:  Mol Gen Genet       Date:  1994-10-28

10.  Yeast Elongator protein Elp1p does not undergo proteolytic processing in exponentially growing cells.

Authors:  Hao Xu; Joakim Bygdell; Gunnar Wingsle; Anders S Byström
Journal:  Microbiologyopen       Date:  2015-09-25       Impact factor: 3.139
  10 in total

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